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dc.contributor.authorSabapathy, Surendranen_US
dc.contributor.authorAwater, Marcen_US
dc.contributor.authorSchneider, Donalden_US
dc.contributor.authorKingsley, Rebeccaen_US
dc.contributor.authorE Hopman, Mariaen_US
dc.contributor.authorMorris, Normanen_US
dc.contributor.editorRichard Russellen_US
dc.date.accessioned2017-05-03T13:17:49Z
dc.date.available2017-05-03T13:17:49Z
dc.date.issued2006en_US
dc.date.modified2009-01-20T06:12:32Z
dc.identifier.issn11769106en_US
dc.identifier.urihttp://hdl.handle.net/10072/14260
dc.description.abstractWe compared exercise capacity (peak O2 uptake) and lower limb vasodilatory capacity in 9 patients with moderate chronic obstructive pulmonary disease (COPD) (forced expiratory volume in 1 s = 55 ᠳ % predicted) and 9 age-matched healthy control subjects. Peak O2 uptake was measured via open circuit spirometry during incremental cycling. Calf blood flow (CBF) measurements were obtained at rest and after 5 minutes of ischemia using venous occlusion plethysmography. While peak O2 uptake was significantly lower in the COPD patients (15.8 ᠳ.5 mL/min/kg) compared to the control group (25.2 ᠳ.5 mL/kg/min), there were no significant differences between groups in peak CBF or peak calf conductance measured 7 s post-ischemia. peak O2 uptake was significantly correlated with peak CBF and peak conductance in the control group, whereas there was no significant relationship found between these variables in the COPD group. However, the rate of decay in blood flow following ischemia was significantly slower (p<0.05) for the COPD group (-0.036 ᠰ.005 mL/100 mL/min/s) when compared to controls (-0.048 ᠰ.015 mL/100 mL/min/s). The results suggest that the lower peak exercise capacity in patients with moderate COPD is not related to a loss in leg vasodilatory capacity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherDove Medical Pressen_US
dc.publisher.placeNew Zealanden_US
dc.publisher.urihttps://www.dovepress.com/lower-limb-vasodilatory-capacity-is-not-reduced-in-patients-with-moder-peer-reviewed-article-COPDen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom73en_US
dc.relation.ispartofpageto81en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalInternational Journal of Chronic Obstructive Pulmonary Diseaseen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode321027en_US
dc.subject.fieldofresearchcode320603en_US
dc.subject.fieldofresearchcode321401en_US
dc.titleLower limb vasodilatory capacity is not reduced in patients with moderate COPDen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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