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dc.contributor.authorZamora, Adriana Pliego
dc.contributor.authorEdmonds, Judith H
dc.contributor.authorReynolds, Maxwell J
dc.contributor.authorKhromykh, Alexander A
dc.contributor.authorRalph, Stephen J
dc.date.accessioned2018-11-06T04:22:20Z
dc.date.available2018-11-06T04:22:20Z
dc.date.issued2016
dc.identifier.issn0042-6822
dc.identifier.doi10.1016/j.virol.2016.04.021
dc.identifier.urihttp://hdl.handle.net/10072/142664
dc.description.abstractWest Nile Virus (WNV) is a mosquito-borne flavivirus that can cause neuroinvasive disease in humans and animals for which no therapies are currently available. We studied an established combination of monoterpene alcohols (CMA) derived from Melaleuca alternifolia, against WNV infection. The in vitro results show that CMA exhibits virucidal activity, as well as reduces the viral titres and percentage of infected cells. The antiviral mechanism of action of CMA was studied. We found that CMA did not alter the intracellular pH, neither induced apoptosis, but did induce cell cycle arrest in the G0/G1-phase although that was not the antiviral mechanism. Furthermore, we tested CMA in vivo using IRF 3−/−/7−/−mice and it was found that CMA treatment significantly delayed morbidity due to WNV infection, reduced the loss of body weight and reduced the viral titres in brain. These findings suggest that CMA could be a therapeutic agent against WNV infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.relation.ispartofpagefrom18
dc.relation.ispartofpageto32
dc.relation.ispartofjournalVirology
dc.relation.ispartofvolume495
dc.subject.fieldofresearchEnvironmental and Occupational Health and Safety
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode111705
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleThe in vitro and in vivo antiviral properties of combined monoterpene alcohols against West Nile virus infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorRalph, Stephen J.
gro.griffith.authorReynolds, Maxwell
gro.griffith.authorPliego-Zamora, Adriana C.


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