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dc.contributor.authorLee, Ming-Huei
dc.contributor.authorChang, Kun-Min
dc.contributor.authorWu, Shang-Liang
dc.contributor.authorLin, Hsuan-Hung
dc.contributor.authorLin, Hsiu-Ying
dc.contributor.authorWu, Huei-Ching
dc.date.accessioned2018-10-17T01:15:49Z
dc.date.available2018-10-17T01:15:49Z
dc.date.issued2016
dc.identifier.issn0937-3462
dc.identifier.doi10.1007/s00192-016-2983-y
dc.identifier.urihttp://hdl.handle.net/10072/142718
dc.description.abstractIntroduction and hypothesis: Symptoms of interstitial cystitis/bladder pain syndrome (IC/BPS) are often confused with uterine conditions. Gynecologists may therefore recommend hysterectomy which was inappropriate for these patients. This study investigated whether IC/BPS increases the risk of hysterectomy in a large nationwide retrospective cohort study. Methods: From the Longitudinal Health Insurance Database 2010 (LHID2010) in Taiwan, we identified women diagnosed with IC/BPS between 2002 and 2013. Those with a history of hysterectomy before IC/BPS diagnosis were excluded. All women were stratified into three subgroups (younger, middle, older age) based on the propensity scores of 15 confounding factors, including age and comorbidities. All were followed until the end of 2013 to detect the event of hysterectomy. The hazard ratio (HR) of hysterectomy in the IC/BPS cohort was compared with the non-IC/BPS cohort among the three subgroups by Cox regression after adjusting for confounding factors. Results: In addition to the representative middle age, subgroup 2 had similar rates of comorbidities as the general population. The study was both externally and internally valid. The risk of hysterectomy in the IC/BPS cohort (n = 536) was significantly higher than in the non-IC/BPS cohort (n = 103846) in subgroup 2 (HR = 1.701, 95 % CI 1.056–2.740). The mean time to hysterectomy after diagnosis of IC/BPS was 2.97 years. Conclusions: In this nationwide study, we found that IC/BPS has a causal impact on hysterectomy in the middle-age subgroup in LHID 2010. The possibility of a woman having IC/BPS should be evaluated prior to hysterectomy to avoid inappropriate surgery.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer-Verlag London Ltd
dc.relation.ispartofpagefrom1401
dc.relation.ispartofpageto1407
dc.relation.ispartofissue9
dc.relation.ispartofjournalInternational Urogynecology Journal
dc.relation.ispartofvolume27
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode111499
dc.subject.fieldofresearchcode1114
dc.titleA cohort study of interstitial cystitis/bladder pain syndrome and hysterectomy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWu, Shang-Liang


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