dc.contributor.author | Loughrey, Bradley T | |
dc.contributor.author | Williams, Michael L | |
dc.contributor.author | Parsons, Peter G | |
dc.contributor.author | Healy, Peter C | |
dc.date.accessioned | 2019-02-28T05:35:33Z | |
dc.date.available | 2019-02-28T05:35:33Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0022-328X | |
dc.identifier.doi | 10.1016/j.jorganchem.2016.06.012 | |
dc.identifier.uri | http://hdl.handle.net/10072/142763 | |
dc.description.abstract | This article outlines the synthesis of an electrophilic organoruthenium carboxylic acid of the structure [(η5-Cp*)Ru(η6-C6H5CO2H)]+ and explores the behavior of this molecule under a variety of nucleophilic substitution conditions using a range of oxygen and nitrogen based nucleophiles including alcohols, primary and secondary amines and aromatic sulfonamides. The resulting organoruthenium ester [(η5-Cp*)Ru(η6-C6H5COOR)]+ and amide [(η5-Cp*)Ru(η6-C6H5CONHR)]+ or [(η5-Cp*)Ru(η6-C6H5CONR)]+ complexes are additionally reported. All prepared complexes have been fully characterized using Fourier-transform IR and NMR spectroscopy and electrospray mass spectrometry with single-crystal X-ray structural determinations reported for three complexes: 3[(η5-Cp*)Ru(η6-C6H5CO2H)]B(C6H5)4.[(η5-Cp*)Ru(η6-C6H5CO2)].H2O, [(η5-Cp*)Ru(η6-C6H5CONHCH2Ph)]PF6 and [(η5-Cp*)Ru(η6-C6H5CONHSO2C6H4COMe)]PF6. Complexes were also evaluated for in vitro cytotoxic activity against the MCF7 (hormone-dependant breast cancer), MDA-MD-231 (hormone-independent breast cancer), MM96L (human melanoma) tumourigenic cell lines and the normal NFF (neonatal foreskin fibroblasts) human cell line. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 1 | |
dc.relation.ispartofpageto | 10 | |
dc.relation.ispartofjournal | Journal of Organometallic Chemistry | |
dc.relation.ispartofvolume | 819 | |
dc.subject.fieldofresearch | Inorganic chemistry | |
dc.subject.fieldofresearch | Inorganic chemistry not elsewhere classified | |
dc.subject.fieldofresearch | Organic chemistry | |
dc.subject.fieldofresearch | Other chemical sciences | |
dc.subject.fieldofresearchcode | 3402 | |
dc.subject.fieldofresearchcode | 340299 | |
dc.subject.fieldofresearchcode | 3405 | |
dc.subject.fieldofresearchcode | 3499 | |
dc.title | Nucleophilic substitution reactions of [(η5-Cp*)Ru(η6-C6H5CO2H)]+: Synthesis, characterization and cytotoxicity of organoruthenium ester and amide complexes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Sciences, School of Natural Sciences | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Healy, Peter C. | |