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dc.contributor.authorZare-Bidaki, Mohammad
dc.contributor.authorAssar, Shokrollah
dc.contributor.authorHakimi, Hamid
dc.contributor.authorAbdollahi, Seyyed Hossein
dc.contributor.authorNosratabadi, Reza
dc.contributor.authorKennedy, Derek
dc.contributor.authorArababadi, Mohammad Kazemi
dc.date.accessioned2018-01-05T05:14:21Z
dc.date.available2018-01-05T05:14:21Z
dc.date.issued2016
dc.identifier.issn1043-4666
dc.identifier.doi10.1016/j.cyto.2016.07.002
dc.identifier.urihttp://hdl.handle.net/10072/142849
dc.description.abstractToxoplasma gondii (T. gondii) is an obligate intracellular protozoan causing several forms of toxoplasmosis in humans. The main mechanisms that allow the development of the prolonged forms of the disease and its subsequent pathology are yet to be clarified. However, many researchers have hypothesized that immunological and genetic parameters may play crucial roles in the etiology of the disease. Transforming growth factor beta (TGF-β) is a cytokine with a dual role in the regulation of immune responses including those against parasites. However, the relationship between TGF-β and immune responses against T .gondii are not fully understood. The important roles played by TGF-β in the development of Th17 and T regulatory lymphocytes, mucosal immunity and regulation of immune responses have been documented and this provides insights into TGF-β function during parasitic infections such as toxoplasmosis. Therefore, the aim of this review is to collate the current information regarding the status and association of TGF-β with T. gondii infection.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom29
dc.relation.ispartofpageto35
dc.relation.ispartofjournalCytokine
dc.relation.ispartofvolume86
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode1107
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode0604
dc.titleTGF-β in Toxoplasmosis: Friend or foe?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKennedy, Derek D.


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