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dc.contributor.authorBaptista, Natalie M
dc.contributor.authorChristensen, Kurt D
dc.contributor.authorCarere, Deanna Alexis
dc.contributor.authorBroadley, Simon A
dc.contributor.authorRoberts, J Scott
dc.contributor.authorGreen, Robert C
dc.date.accessioned2018-10-22T01:42:52Z
dc.date.available2018-10-22T01:42:52Z
dc.date.issued2016
dc.identifier.issn1098-3600
dc.identifier.doi10.1038/gim.2015.192
dc.identifier.urihttp://hdl.handle.net/10072/142889
dc.description.abstractPurpose: American adult adoptees may possess limited information about their biological families and turn to direct-to-consumer personal genomic testing (PGT) for genealogical and medical information. We investigated the motivations and outcomes of adoptees undergoing PGT using data from the Impact of Personal Genomics (PGen) Study. Methods: The PGen Study surveyed new 23andMe and Pathway Genomics customers before and 6 months after receiving PGT results. Exploratory analyses compared adoptees’ and nonadoptees’ PGT attitudes, expectations, and experiences. We evaluated the association of adoption status with motivations for testing and postdisclosure actions using logistic regression models. Results: Of 1,607 participants, 80 (5%) were adopted. As compared with nonadoptees, adoptees were more likely to cite limited knowledge of family health history (OR = 10.1; 95% CI = 5.7–19.5) and the opportunity to learn genetic disease risks (OR = 2.7; 95% CI = 1.6–4.8) as strong motivations for PGT. Of 922 participants who completed 6-month follow-up, there was no significant association between adoption status and PGT-motivated health-care utilization or health-behavior change. Conclusion: PGT allows adoptees to gain otherwise inaccessible information about their genetic disease risks and ancestry, helping them to fill the void of an incomplete family health history.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom924
dc.relation.ispartofpageto932
dc.relation.ispartofjournalGenetics in Medicine
dc.relation.ispartofvolume18
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchGenetics not elsewhere classified
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode310599
dc.subject.fieldofresearchcode3202
dc.titleAdopting genetics: motivations and outcomes of personal genomic testing in adult adoptees
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.facultyAn Unassigned Group, An Unassigned Department
gro.rights.copyright© 2016 Nature Publishing Group. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorBroadley, Simon


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