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  • The role of CXCR3 and its ligands in renal transplant outcome

    Author(s)
    Dabiri, Shahriar
    Kariminik, Ashraf
    Kennedy, Derek
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic ...
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    Chemokines and their corresponding receptors serve as pro-inflammatory and migratory signals for immune cells. CXCR3 and its corresponding ligands, CXCL9, CXCL10 and CXCL11, participate in the induction of immune responses against several foreign antigens. Numerous cells, including macrophages, NK cells and T lymphocytes, express CXCR3 and thus, expression of the receptor and its ligands can induce activity of these important immune cells against foreign antigens, including allogeneic grafts. Several parameters of the immune system participate in the induction and stimulation of powerful immune responses against allogeneic grafts. A thorough understanding of the parameters that regulate these responses can provide insights into new methods for immunotherapy during organ transplantation. The aim of this review is to address the most recent information regarding the roles played by CXCR3 and its corresponding ligands in the outcome of renal transplantation.
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    Journal Title
    European Cytokine Network
    Volume
    27
    Issue
    2
    DOI
    https://doi.org/10.1684/ecn.2016.0375
    Subject
    Immunology not elsewhere classified
    Biochemistry and Cell Biology
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/143134
    Collection
    • Journal articles

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