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  • Preclinical immunogenicity and safety of a Group A streptococcal M protein-based vaccine candidate

    Author(s)
    Batzloff, Michael R
    Fane, Anne
    Gorton, Davina
    Pandey, Manisha
    Rivera-Hernandez, Tania
    Calcutt, Ainslie
    Yeung, Grace
    Hartas, Jon
    Johnson, Linda
    Rush, Catherine M
    McCarthy, James
    Ketheesan, Natkunam
    Good, Michael F
    Griffith University Author(s)
    Pandey, Manisha
    Good, Michael F.
    Year published
    2016
    Metadata
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    Abstract
    Streptococcus pyogenes (group A streptococcus, GAS) causes a wide range of clinical manifestations ranging from mild self-limiting pyoderma to invasive diseases such as sepsis. Also of concern are the post-infectious immune-mediated diseases including rheumatic heart disease. The development of a vaccine against GAS would have a large health impact on populations at risk of these diseases. However, there is a lack of suitable models for the safety evaluation of vaccines with respect to post-infectious complications. We have utilized the Lewis Rat model for cardiac valvulitis to evaluate the safety of the J8-DT vaccine ...
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    Streptococcus pyogenes (group A streptococcus, GAS) causes a wide range of clinical manifestations ranging from mild self-limiting pyoderma to invasive diseases such as sepsis. Also of concern are the post-infectious immune-mediated diseases including rheumatic heart disease. The development of a vaccine against GAS would have a large health impact on populations at risk of these diseases. However, there is a lack of suitable models for the safety evaluation of vaccines with respect to post-infectious complications. We have utilized the Lewis Rat model for cardiac valvulitis to evaluate the safety of the J8-DT vaccine formulation in parallel with a rabbit toxicology study. These studies demonstrated that the vaccine did not induce abnormal pathology. We also show that in mice the vaccine is highly immunogenic but that 3 doses are required to induce protection from a GAS skin challenge even though 2 doses are sufficient to induce a high antibody titer.
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    Journal Title
    Human Vaccines & Immunotherapeutics
    DOI
    https://doi.org/10.1080/21645515.2016.1222999
    Subject
    Immunology
    Immunology not elsewhere classified
    Medical microbiology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/143176
    Collection
    • Journal articles

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