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  • Biennial versus annual treatment for schistosomiasis and its impact on liver morbidity

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    Author(s)
    Olveda, David U
    Inobaya, Marianette T
    McManus, Donald P
    Olveda, Remigio M
    Vinluan, Marilyn L
    Ng, Shu-Kay
    Harn, Donald A
    Li, Yuesheng
    Guevarra, Jerric R
    Lam, Alfred K
    Ross, Allen GP
    Griffith University Author(s)
    Lam, Alfred K.
    Ng, Shu Kay Angus
    Ross, Allen G.
    Olveda, David
    Inobaya, Marianette
    Year published
    2017
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    Abstract
    Objective: This study assessed the impact of annual versus biennial praziquantel treatment regimens on the prevalence, intensity of infection, and liver fibrosis dynamics of Asiatic schistosomiasis (caused by Schistosoma japonicum) among individuals residing in 18 endemic barangays in Northern Samar, Philippines. Methods: Five hundred and sixty-five subjects who reported symptoms of gastrointestinal illness and/or were believed to have clinical morbidity based on physical examination were selected for cohort follow-up. Results: The mean prevalence of schistosomiasis was 34% and the mean intensity of infection was 123.1 ...
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    Objective: This study assessed the impact of annual versus biennial praziquantel treatment regimens on the prevalence, intensity of infection, and liver fibrosis dynamics of Asiatic schistosomiasis (caused by Schistosoma japonicum) among individuals residing in 18 endemic barangays in Northern Samar, Philippines. Methods: Five hundred and sixty-five subjects who reported symptoms of gastrointestinal illness and/or were believed to have clinical morbidity based on physical examination were selected for cohort follow-up. Results: The mean prevalence of schistosomiasis was 34% and the mean intensity of infection was 123.1 eggs per gram. Moderate to severe hepatic fibrosis (grade II/III) was demonstrated in approximately 25% of the study population. As expected, a greater reduction in both the prevalence and intensity of infection was documented with two treatment rounds versus one. Overall, hepatic fibrosis (grades I–III) regressed in only 24.3% of those who received a single treatment and in only 19.3% of those who received two doses. The prevalence of grade II–III fibrosis at baseline (25.2%) remained unchanged 2 years after treatment. Conclusions: These findings suggest that in order to reverse moderate to severe liver fibrosis due to schistosomiasis and improve clinical outcomes, a higher clinical dosage of praziquantel (i.e., 60–80 mg/kg) may be required over an extended duration.
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    Journal Title
    International Journal of Infectious Diseases
    DOI
    https://doi.org/10.1016/j.ijid.2016.10.001
    Copyright Statement
    © 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
    Subject
    Microbiology
    Medical microbiology
    Medical microbiology not elsewhere classified
    Health services and systems
    Public health
    Publication URI
    http://hdl.handle.net/10072/143186
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    • Journal articles

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