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  • Diagnosing schistosomiasis-induced liver morbidity: implications for global control

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    Author(s)
    Olveda, David U
    Inobaya, Marianette
    Olveda, Remigio M
    Vinluan, Marilyn L
    Ng, Shu-Kay
    Weerakoon, Kosala
    McManus, Donald P
    Ramm, Grant A
    Harn, Donald A
    Li, Yuesheng
    Lam, Alfred K
    Guevarra, Jerric R
    Ross, Allen G
    Griffith University Author(s)
    Lam, Alfred K.
    Ng, Shu Kay Angus
    Ross, Allen G.
    Olveda, David
    Inobaya, Marianette
    Year published
    2017
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    Abstract
    Background: Subclinical morbidity due to schistosomiasis was evaluated in 565 patients, and the enhanced liver fibrosis (ELF) test was assessed for the first time as a potential screening tool for disease. Methods: The prevalence and intensity of infection were determined by Kato–Katz thick smear stool examination at baseline and 2 years after curative treatment. The degree of hepatic fibrosis was assessed by ultrasound. Non-invasive serum biomarkers of hepatic fibrosis were also evaluated. Results: The baseline human prevalence and infection intensity were found to be moderately high at 34% and 123 eggs per gram, ...
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    Background: Subclinical morbidity due to schistosomiasis was evaluated in 565 patients, and the enhanced liver fibrosis (ELF) test was assessed for the first time as a potential screening tool for disease. Methods: The prevalence and intensity of infection were determined by Kato–Katz thick smear stool examination at baseline and 2 years after curative treatment. The degree of hepatic fibrosis was assessed by ultrasound. Non-invasive serum biomarkers of hepatic fibrosis were also evaluated. Results: The baseline human prevalence and infection intensity were found to be moderately high at 34% and 123 eggs per gram, respectively. However, hepatic parenchymal fibrosis occurred in 50% of subjects, with grade II fibrosis in 19% and grade III in 6%. The ELF score and higher serum levels of tissue inhibitor of metalloproteinase 1 (TIMP-1) and hyaluronic acid (HA) correlated with the grade of liver fibrosis. Conclusions: The findings of this study demonstrated that praziquantel treatment had a short-term impact on both the prevalence and intensity of infection, but less of an impact on established morbidity. Higher TIMP-1 and HA serum levels, and an ELF cut-off score of 8 were found to be correlated with the grade of liver fibrosis; these values may, therefore, assist physicians in identifying individuals at greater risk of disease.
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    Journal Title
    International Journal of Infectious Diseases
    DOI
    https://doi.org/10.1016/j.ijid.2016.10.024
    Copyright Statement
    © 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
    Subject
    Microbiology
    Medical microbiology
    Medical microbiology not elsewhere classified
    Health services and systems
    Public health
    Publication URI
    http://hdl.handle.net/10072/143187
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    • Journal articles

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