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  • Cell Biology of Membrane Trafficking in Human Disease

    Author(s)
    Howell, Gareth J
    Holloway, Zoe G
    Cobbold, Christian
    Monaco, Anthony P
    Ponnambalam, Sreenivasan
    Griffith University Author(s)
    Cobbold, Christian J.
    Year published
    2006
    Metadata
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    Abstract
    Understanding the molecular and cellular mechanisms underlying membrane traffic pathways is crucial to the treatment and cure of human disease. Different human diseases caused by changes in cellular homeostasis arise through single gene mutation(s) resulting in compromised membrane trafficking. Many pathogenic agents such as viruses, bacteria or parasites have evolved mechanisms to subvert the host cell response to infection, or have hijacked cellular mechanisms to proliferate and ensure pathogen survival. Understanding the consequence of genetic mutations or pathogenic infection on membrane traffic has also enabled greater ...
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    Understanding the molecular and cellular mechanisms underlying membrane traffic pathways is crucial to the treatment and cure of human disease. Different human diseases caused by changes in cellular homeostasis arise through single gene mutation(s) resulting in compromised membrane trafficking. Many pathogenic agents such as viruses, bacteria or parasites have evolved mechanisms to subvert the host cell response to infection, or have hijacked cellular mechanisms to proliferate and ensure pathogen survival. Understanding the consequence of genetic mutations or pathogenic infection on membrane traffic has also enabled greater understanding of the interactions between organisms and the surrounding environment. This review will focus on human genetic defects and molecular mechanisms that underlie eukaryote exocytosis and endocytosis and current and future prospects for alleviation of a variety of human diseases.
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    Journal Title
    International Review of Cytology
    Volume
    252
    Subject
    Biochemistry and cell biology
    Publication URI
    http://hdl.handle.net/10072/14331
    Collection
    • Journal articles

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