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dc.contributor.authorWhite, H
dc.contributor.authorBird, R
dc.contributor.authorSosnowski, K
dc.contributor.authorJones, M
dc.date.accessioned2018-11-30T01:57:46Z
dc.date.available2018-11-30T01:57:46Z
dc.date.issued2016
dc.identifier.issn1470-2118
dc.identifier.doi10.7861/clinmedicine.16-3-230
dc.identifier.urihttp://hdl.handle.net/10072/143418
dc.description.abstractThrombosis is a complication of many chronic illnesses. Chronic obstructive pulmonary disease (COPD) and diabetes mellitus are common medical conditions frequently associated with a hypercoagulable state. Acidaemia has been shown to reduce coagulation. COPD and diabetes mellitus during acute deterioration can present with a severe acidaemia. The impact of this acidaemia on coagulation is poorly studied. Patients presenting with a diagnosis of diabetic ketoacidosis or type II respiratory failure from COPD and a pH of less than 7.2 were included in our study. A coagulation screen and a thromboelastograph (TEG) were performed on admission and 24 hours later. The mean pH on admission was 7.07 and mean base excess was –16.3. The activated partial thromboplastin time was associated with pH change but remained within the normal range (26–41 s). All other coagulation and TEG parameters failed to show evidence of association (p>0.05). In the two models of non-haemorrhagic acidosis investigated, coagulation was not altered by the changes in pH. More work is needed to understand the complex relationship between factors affecting coagulation in individual disease processes.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRoyal College of Physicians
dc.relation.ispartofpagefrom230
dc.relation.ispartofpageto234
dc.relation.ispartofissue3
dc.relation.ispartofjournalClinical medicine
dc.relation.ispartofvolume16
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchClinical sciences not elsewhere classified
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320299
dc.titleAn in vitro analysis of the effect of acidosis on coagulation in chronic disease states – a thromboelastograph study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© 2016 Royal College of Physicians. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorWhite, Hayden T.
gro.griffith.authorSosnowski, Kellie
gro.griffith.authorBird, Robert


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