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dc.contributor.authorElbaz, Alexisen_US
dc.contributor.authorM. Nelson, Loreneen_US
dc.contributor.authorPayami, Haydehen_US
dc.contributor.authorP.A. Ioannidis, Johnen_US
dc.contributor.authorK. Fiske, Brianen_US
dc.contributor.authorAnnesi, Graziaen_US
dc.contributor.authorBelin, Andrea Carmineen_US
dc.contributor.authorA. Factor, Stewarten_US
dc.contributor.authorFerrarese, Carloen_US
dc.contributor.authorM. Hadjigeorgiou, Georgiosen_US
dc.contributor.authorS. Higgins, Donalden_US
dc.contributor.authorKawakami, Hideshien_US
dc.contributor.authorKruger, Rejkoen_US
dc.contributor.authorS. Marder, Karenen_US
dc.contributor.authorP. Mayeux, Richarden_US
dc.contributor.authorMellick, Georgeen_US
dc.contributor.authorG. Nutt, Johnen_US
dc.contributor.authorRitz, Beateen_US
dc.contributor.authorSamii, Alien_US
dc.contributor.authorM. Tanner, Carolineen_US
dc.contributor.authorVan Broeckhoven, Christineen_US
dc.contributor.authorK. Van Den Eeden, Stephenen_US
dc.contributor.authorWirdefeldt, Karinen_US
dc.contributor.authorP. Zabetian, Cyrusen_US
dc.contributor.authorDehem, Marieen_US
dc.contributor.authorS. Montimurro, Jenniferen_US
dc.contributor.authorSouthwick, Audreyen_US
dc.contributor.authorM. Myers, Richarden_US
dc.contributor.authorA. Trikalinos, Thomasen_US
dc.description.abstractBackground A genome-wide association study identified 13 single-nucleotide polymorphisms (SNPs) significantly associated with Parkinson's disease. Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain. Methods Investigators from three Michael J Fox Foundation for Parkinson's Research-funded genetics consortia-comprising 14 teams-contributed DNA samples from 5526 patients with Parkinson's disease and 6682 controls, which were genotyped for the 13 SNPs. Most (88%) participants were of white, non-Hispanic descent. We assessed log-additive genetic effects using fixed and random effects models stratified by team and ethnic origin, and tested for heterogeneity across strata. A meta-analysis was undertaken that incorporated data from the original genome-wide study as well as subsequent replication studies. Findings In fixed and random-effects models no associations with any of the 13 SNPs were identified (odds ratios 0縹 to 1簹). Heterogeneity between studies and between ethnic groups was low for all SNPs. Subgroup analyses by age at study entry, ethnic origin, sex, and family history did not show any consistent associations. In our meta-analysis, no SNP showed significant association (summary odds ratios 0繵 to 1.08); there was little heterogeneity except for SNP rs7520966. Interpretation Our results do not lend support to the finding that the 13 SNPs reported in the original genome-wide association study are genetic susceptibility factors for Parkinson's disease.en_US
dc.publisherThe Lancet Publishing Group / Elsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofjournalThe Lancet Neurologyen_US
dc.titleLack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2006 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
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