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dc.contributor.authorLiao, Sam
dc.contributor.authorSimpson, Benjamin
dc.contributor.authorNeidlin, Michael
dc.contributor.authorKaufmann, Tim AS
dc.contributor.authorLi, Zhiyong
dc.contributor.authorWoodruff, Maria A
dc.contributor.authorGregory, Shaun D
dc.date.accessioned2017-07-10T04:44:30Z
dc.date.available2017-07-10T04:44:30Z
dc.date.issued2016
dc.identifier.issn1475-925X
dc.identifier.doi10.1186/s12938-016-0262-2
dc.identifier.urihttp://hdl.handle.net/10072/143629
dc.description.abstractBackground: Implantation of a rotary blood pump (RBP) can cause non-physiological flow fields in the left ventricle (LV) which may trigger thrombosis. Different inflow cannula geometry can affect LV flow fields. The aim of this study was to determine the effect of inflow cannula geometry on intraventricular flow under full LV support in a patient specific model. Methods: Computed tomography angiography imaging of the LV was performed on a RBP candidate to develop a patient-specific model. Five inflow cannulae were evaluated, which were modelled on those used clinically or under development. The inflow cannulae are described as a crown like tip, thin walled tubular tip, large filleted tip, trumpet like tip and an inferiorly flared cannula. Placement of the inflow cannula was at the LV apex with the central axis intersecting the centre of the mitral valve. Full support was simulated by prescribing 5 l/min across the mitral valve. Thrombus risk was evaluated by identifying regions of stagnation. Rate of LV washout was assessed using a volume of fluid model. Relative haemolysis index and blood residence time was calculated using an Eulerian approach. Results: The inferiorly flared inflow cannula had the lowest thrombus risk due to low stagnation volumes. All cannulae had similar rates of LV washout and blood residence time. The crown like tip and thin walled tubular tip resulted in relatively higher blood damage indices within the LV. Conclusion: Changes in intraventricular flow due to variances in cannula geometry resulted in different stagnation volumes. Cannula geometry does not appreciably affect LV washout rates and blood residence time. The patient specific, full support computational fluid dynamic model provided a repeatable platform to investigate the effects of inflow cannula geometry on intraventricular flow.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.relation.ispartofpagefrom588
dc.relation.ispartofpageto604
dc.relation.ispartofissue135 (Suppl 2)
dc.relation.ispartofjournalBioMedical Engineering OnLine
dc.relation.ispartofvolume15
dc.subject.fieldofresearchBiomedical engineering
dc.subject.fieldofresearchMedical devices
dc.subject.fieldofresearchcode4003
dc.subject.fieldofresearchcode400308
dc.titleNumerical prediction of thrombus risk in an anatomically dilated left ventricle: the effect of inflow cannula designs
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorSimpson, Benjamin A.
gro.griffith.authorGregory, Shaun D.


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