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  • Novel platform technology for modular mucosal vaccine that protects against streptococcus

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    ZamanPUB3948.pdf (1.282Mb)
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    Version of Record (VoR)
    Author(s)
    Zaman, Mehfuz
    Ozberk, Victoria
    Langshaw, Emma L
    McPhun, Virginia
    Powell, Jessica L
    Phillips, Zachary N
    Ho, Mei Fong
    Calcutt, Ainslie
    Batzloff, Michael R
    Toth, Istvan
    Hill, Geoffrey R
    Pandey, Manisha
    Good, Michael F
    Griffith University Author(s)
    Batzloff, Michael R.
    Pandey, Manisha
    Good, Michael F.
    Ozberk, Victoria
    Dooley, Jessica L.
    McPhun, Virginia
    Zaman, Mehfuz
    Langshaw, Emma
    Calcutt, Ainslie M.
    Ho, Mei Fong
    Phillips5140081, ZakDNU N.
    Phillips, Zachary N.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    The upper respiratory tract (URT) is the major entry site for human pathogens and strategies to activate this network could lead to new vaccines capable of preventing infection with many pathogens. Group A streptococcus (GAS) infections, causing rheumatic fever, rheumatic heart disease, and invasive disease, are responsible for substantial morbidity and mortality. We describe an innovative vaccine strategy to induce mucosal antibodies of significant magnitude against peptide antigens of GAS using a novel biocompatible liposomal platform technology. The approach is to encapsulate free diphtheria toxoid (DT), a standard vaccine ...
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    The upper respiratory tract (URT) is the major entry site for human pathogens and strategies to activate this network could lead to new vaccines capable of preventing infection with many pathogens. Group A streptococcus (GAS) infections, causing rheumatic fever, rheumatic heart disease, and invasive disease, are responsible for substantial morbidity and mortality. We describe an innovative vaccine strategy to induce mucosal antibodies of significant magnitude against peptide antigens of GAS using a novel biocompatible liposomal platform technology. The approach is to encapsulate free diphtheria toxoid (DT), a standard vaccine antigen, within liposomes as a source of helper T-cell stimulation while lipidated peptide targets for B-cells are separately displayed on the liposome surface. As DT is not physically conjugated to the peptide, it is possible to develop modular epitopic constructs that simultaneously activate IgA-producing B-cells of different and complementary specificity and function that together neutralize distinct virulence factors. An inflammatory cellular immune response is also induced. The immune response provides profound protection against streptococcal infection in the URT. The study describes a new vaccine platform for humoral and cellular immunity applicable to the development of vaccines against multiple mucosal pathogens.
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    Journal Title
    Scientific Reports
    Volume
    6
    DOI
    https://doi.org/10.1038/srep39274
    Copyright Statement
    © The Author(s). 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
    Subject
    Biochemistry and cell biology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/143666
    Collection
    • Journal articles

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