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dc.contributor.authorZaman, Mehfuz
dc.contributor.authorOzberk, Victoria
dc.contributor.authorLangshaw, Emma L
dc.contributor.authorMcPhun, Virginia
dc.contributor.authorPowell, Jessica L
dc.contributor.authorPhillips, Zachary N
dc.contributor.authorHo, Mei Fong
dc.contributor.authorCalcutt, Ainslie
dc.contributor.authorBatzloff, Michael R
dc.contributor.authorToth, Istvan
dc.contributor.authorHill, Geoffrey R
dc.contributor.authorPandey, Manisha
dc.contributor.authorGood, Michael F
dc.date.accessioned2018-01-18T04:39:54Z
dc.date.available2018-01-18T04:39:54Z
dc.date.issued2016
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep39274
dc.identifier.urihttp://hdl.handle.net/10072/143666
dc.description.abstractThe upper respiratory tract (URT) is the major entry site for human pathogens and strategies to activate this network could lead to new vaccines capable of preventing infection with many pathogens. Group A streptococcus (GAS) infections, causing rheumatic fever, rheumatic heart disease, and invasive disease, are responsible for substantial morbidity and mortality. We describe an innovative vaccine strategy to induce mucosal antibodies of significant magnitude against peptide antigens of GAS using a novel biocompatible liposomal platform technology. The approach is to encapsulate free diphtheria toxoid (DT), a standard vaccine antigen, within liposomes as a source of helper T-cell stimulation while lipidated peptide targets for B-cells are separately displayed on the liposome surface. As DT is not physically conjugated to the peptide, it is possible to develop modular epitopic constructs that simultaneously activate IgA-producing B-cells of different and complementary specificity and function that together neutralize distinct virulence factors. An inflammatory cellular immune response is also induced. The immune response provides profound protection against streptococcal infection in the URT. The study describes a new vaccine platform for humoral and cellular immunity applicable to the development of vaccines against multiple mucosal pathogens.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Macmillan
dc.relation.ispartofpagefrom39274-1
dc.relation.ispartofpageto39274-11
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume6
dc.relation.urihttp://purl.org/au-research/grants/NHMRC/APP1069915
dc.relation.grantIDAPP1069915
dc.relation.fundersNHMRC
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchcode310199
dc.titleNovel platform technology for modular mucosal vaccine that protects against streptococcus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomics
gro.rights.copyright© The Author(s). 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorPandey, Manisha
gro.griffith.authorGood, Michael F.
gro.griffith.authorOzberk, Victoria
gro.griffith.authorZaman, Mehfuz


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