Naseseazine C, a new anti-plasmodial dimeric diketopiperazine from a marine sediment derived Streptomyces sp.

A new dimeric diketopiperazine, naseseazine C, and the known naseseazines A and B were isolated from solid culture extracts of an Australian marine sediment derived Streptomyces species. Naseseazine C displayed a new C-6′/C-3 linkage between the two diketopiperazine subunits and showed moderate activity against the chloroquine-sensitive malaria parasite, Plasmodium falciparum (3D7 strain).A new dimeric diketopiperazine, naseseazine C, and the known naseseazines A and B were isolated from solid culture extracts of an Australian marine sediment derived Streptomyces species. Naseseazine C displayed a new C-6′/C-3 linkage between the two diketopiperazine subunits and showed moderate activity against the chloroquine-sensitive malaria parasite, Plasmodium falciparum (3D7 strain).
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Journal Title

Tetrahedron Letters

Volume

Issue

DOI

https://doi.org/10.1016/j.tetlet.2016.11.071

Subject

Medicinal and Biomolecular Chemistry not elsewhere classified

Medicinal and Biomolecular Chemistry

Organic Chemistry

Publication URI

http://hdl.handle.net/10072/143678

Collection

Journal articles