Biocompatible Fibres Promote Lineated Growth and Migration of Neural Progenitor Cells With Potential Applications In Nerve Bioregeneration
Presently, there is no cure for central nervous system damage. The use of various biocompatible materials is being investigated to guide neural and glial cells to repair damaged nerves. Biocompatible materials must be capable of being used in or on the human body without eliciting a rejection response from the surrounding body tissues. They must pass stringent tests to assure that they will not cause inflammation, infection, thrombogenesis, adverse immunological response or neoplastic induction or promotion. We have developed and optimized a process to apply to a biocompatible fibre that possesses minimal immunogenicity and can withstand modification and sterilization procedures, plus maintain its integrity throughout long-term tissue culture in vitro. In tests to date, the biocompatible fibres have lasted for periods of longer than 6 months in continuous in vitro cell culture conditions. The scaffold appears to be ideal in enhancing the linearization and the directional migration of cells, particularly those of neural and glial origins. Such a property would be superlative in the field of tissue engineering, especially from the perspective of nerve regeneration and repair. The biocompatible fibre (cell seeded or unseeded) has been shown in vitro to enhance glial and neuronal directional alignments, and aid in the growth of lineated nerve tissue, which may be more suitable and conducive for nerve and spinal cord repair The poster will present more information on the outcomes of the current studies conducted. Griffith is seeking a commercial and research relationship with companies in the field of tissue engineering and in particular those with specific interest in nerve regeneration and repair. Contact Dr Ann McDonnell at A.McDonnell@griffith.edu.au or Brian Smith on +61 (0) 754 742.
Innovation Corridor Abstract: Biocompatible Fibres Promote Lineated Growth and Migration of Neural Progenitor Cells With Potential Applications In Nerve Bioregeneration