Association of APOE with Parkinson disease age-at-onset in women

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Author(s)
Buchanan, Daniel D
Silburn, Peter A
Prince, Jonathan A
Mellick, George D
Griffith University Author(s)
Year published
2007
Metadata
Show full item recordAbstract
APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P = 0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P = 0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.
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Journal Title
Neuroscience Letters
Volume
411
Issue
3
Publisher URI
Copyright Statement
© 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
Subject
Neurosciences
Cognitive and computational psychology