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  • Association of APOE with Parkinson disease age-at-onset in women

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    Author(s)
    Buchanan, Daniel D
    Silburn, Peter A
    Prince, Jonathan A
    Mellick, George D
    Griffith University Author(s)
    Mellick, George
    Year published
    2007
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    Abstract
    APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P = 0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.APOE polymorphism has received extensive attention as a risk factor for Parkinson's disease (PD), but findings have been equivocal. Analysis of APOE variants in an Australian PD case-control sample revealed a robust association between genotype and age-at-onset (AAO) of PD in women (P = 0.0008). These data not only further implicate APOE in PD, but also provide a stark example of the effects that gender may play in complex disorders.
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    Journal Title
    Neuroscience Letters
    Volume
    411
    Issue
    3
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/506081/description#description
    DOI
    https://doi.org/10.1016/j.neulet.2006.07.080
    Copyright Statement
    © 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
    Subject
    Neurosciences
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/14941
    Collection
    • Journal articles

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