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dc.contributor.authorTajouri, Lotfien_US
dc.contributor.authorFernandez, Francescaen_US
dc.contributor.authorTajouri, Sophieen_US
dc.contributor.authorDetriche, Geraldineen_US
dc.contributor.authorSzvetko, Attilaen_US
dc.contributor.authorColson, Natalieen_US
dc.contributor.authorCsurhes, Peteren_US
dc.contributor.authorP. Pender, Michaelen_US
dc.contributor.authorGriffiths, Lynen_US
dc.contributor.editorDr. Robert P Lisaken_US
dc.date.accessioned2017-04-24T08:59:27Z
dc.date.available2017-04-24T08:59:27Z
dc.date.issued2007en_US
dc.date.modified2009-01-23T05:39:10Z
dc.identifier.issn0022510Xen_US
dc.identifier.doi10.1016/j.jns.2006.09.018en_AU
dc.identifier.urihttp://hdl.handle.net/10072/14981
dc.description.abstractMultiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a ratio of 3:2 female to male. Objectives: To investigate variation within the estrogen receptor 1 (ESR1) polymorphism gene in an Australian MS case-control population using two intragenic restriction fragment length polymorphisms; the G594A located in exon 8 detected with the BtgI restriction enzyme and T938C located in intron 1, detected with PvuII. One hundred and ten Australian MS patients were studied, with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or Primary Progressive MS (PP-MS). Also, 110 age, sex and ethnicity matched controls were investigated as a comparative group. No significant difference in the allelic distribution frequency was found between the case and control groups for the ESR1 PvuII (P=0.50) and Btg1 (P=0.45) marker. Our results do not support a role for these two ESR1 markers in multiple sclerosis susceptibility, however other markers within ESR1 should not be excluded for potential involvement in the disorder.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier B.V.en_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506078/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom9en_US
dc.relation.ispartofpageto12en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalJournal of the Neurlogical Sciencesen_US
dc.relation.ispartofvolume252en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270210en_US
dc.titleAllelic variation investigation of the estrogen receptor within an Australian multiple sclerosis populationen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medicineen_US
gro.rights.copyrightCopyright 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2007
gro.hasfulltextNo Full Text


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