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  • Coronin 3 involvement in F-actin-dependent processes at the cell cortex

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    Author(s)
    Rosentreter, Andre
    Hofmann, Andreas
    Xavier, Charles-Peter
    Stumpf, Maria
    Noegel, Angelika A
    Clemen, Christoph S
    Griffith University Author(s)
    Hofmann, Andreas
    Year published
    2007
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    Abstract
    The actin interaction of coronin 3 has been mainly documented by in vitro experiments. Here, we discuss coronin 3 properties in the light of new structural information and focus on assays that reflect in vivo roles of coronin 3 and its impact on F-actin-associated functions. Using GFP-tagged coronin 3 fusion proteins and RNAi silencing we show that coronin 3 has roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion. During formation of cell protrusions actin accumulation precedes the focal enrichment of coronin 3 suggesting a role for coronin 3 in events that ...
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    The actin interaction of coronin 3 has been mainly documented by in vitro experiments. Here, we discuss coronin 3 properties in the light of new structural information and focus on assays that reflect in vivo roles of coronin 3 and its impact on F-actin-associated functions. Using GFP-tagged coronin 3 fusion proteins and RNAi silencing we show that coronin 3 has roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion. During formation of cell protrusions actin accumulation precedes the focal enrichment of coronin 3 suggesting a role for coronin 3 in events that follow the initial F-actin assembly. Moreover, we show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events.
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    Journal Title
    Experimental Cell Research
    Volume
    313
    DOI
    https://doi.org/10.1016/j.yexcr.2006.12.015
    Copyright Statement
    © 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biochemistry and cell biology
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/14982
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    • Journal articles

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