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dc.contributor.authorRosentreter, Andreen_US
dc.contributor.authorHofmann, Andreasen_US
dc.contributor.authorXavier, Charles-Peteren_US
dc.contributor.authorStumpf, Mariaen_US
dc.contributor.authorA. Noegel, Angelikaen_US
dc.contributor.authorS. Clemen, Christophen_US
dc.date.accessioned2017-04-24T12:51:27Z
dc.date.available2017-04-24T12:51:27Z
dc.date.issued2007en_US
dc.identifier.issn0014-4827en_US
dc.identifier.doi10.1016/j.yexcr.2006.12.015en_US
dc.identifier.urihttp://hdl.handle.net/10072/14982
dc.description.abstractThe actin interaction of coronin 3 has been mainly documented by in vitro experiments. Here, we discuss coronin 3 properties in the light of new structural information and focus on assays that reflect in vivo roles of coronin 3 and its impact on F-actin-associated functions. Using GFP-tagged coronin 3 fusion proteins and RNAi silencing we show that coronin 3 has roles in wound healing, protrusion formation, cell proliferation, cytokinesis, endocytosis, axonal growth, and secretion. During formation of cell protrusions actin accumulation precedes the focal enrichment of coronin 3 suggesting a role for coronin 3 in events that follow the initial F-actin assembly. Moreover, we show that coronin 3 similar to other coronins interacts with the Arp2/3-complex and cofilin indicating that this family in general is involved in regulating Arp2/3-mediated events.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent4402511 bytes
dc.format.extent156 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherAcademic Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom878en_US
dc.relation.ispartofpageto895en_US
dc.relation.ispartofjournalExperimental Cell Researchen_US
dc.relation.ispartofvolume313en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode270106en_US
dc.titleCoronin 3 involvement in F-actin-dependent processes at the cell cortexen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2007 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2015-05-04T22:04:06Z
gro.hasfulltextFull Text


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