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dc.contributor.authorH. Little, Melissaen_US
dc.contributor.authorBrennan, Janeen_US
dc.contributor.authorGeorgas, Kylieen_US
dc.contributor.authorA. Davies, Jamieen_US
dc.contributor.authorR. Davidson, Duncanen_US
dc.contributor.authorA. Baldock, Richarden_US
dc.contributor.authorBeverdam, Annemieken_US
dc.contributor.authorF. Bertram, Johnen_US
dc.contributor.authorCapel, Blanchen_US
dc.contributor.authorChiu, Han Shengen_US
dc.contributor.authorClements, Daveen_US
dc.contributor.authorCullen-McEwen, Luiseen_US
dc.contributor.authorFleming, Jeanen_US
dc.contributor.authorGilbert, Thierryen_US
dc.contributor.authorHerzlinger, Dorisen_US
dc.contributor.authorHoughton, Dereken_US
dc.contributor.authorH. Kaufman, Matten_US
dc.contributor.authorKleymenova, Elenaen_US
dc.contributor.authorA. Koopman, Peteren_US
dc.contributor.authorG. Lewis, Alforen_US
dc.contributor.authorP. McMahon, Andrewen_US
dc.contributor.authorL. Mendelsohn, Cathyen_US
dc.contributor.authorK. Mitchell, Eleanoren_US
dc.contributor.authorA. Rumballe, Breeen_US
dc.contributor.authorSweeney, Derina E.en_US
dc.contributor.authorTodd Valerius, M.en_US
dc.contributor.authorYamada, Genen_US
dc.contributor.authorYang, Yiyaen_US
dc.contributor.authorYu, Jingen_US
dc.contributor.editorS. Aizawa, M. Leptin, N. Papalopulu, D. Stainier, C.D. Stern, P. Tamen_US
dc.description.abstractCataloguing gene expression during development of the genitourinary tract will increase our understanding not only of this process but also of congenital defects and disease affecting this organ system. We have developed a high-resolution ontology with which to describe the subcompartments of the developing murine genitourinary tract. This ontology incorporates what can be defined histologically and begins to encompass other structures and cell types already identified at the molecular level. The ontology is being used to annotate in situ hybridisation data generated as part of the Genitourinary Development Molecular Anatomy Project (GUDMAP), a publicly available data resource on gene and protein expression during genitourinary development. The GUDMAP ontology encompasses Theiler stage (TS) 17-27 of development as well as the sexually mature adult. It has been written as a partonomic, text-based, hierarchical ontology that, for the embryological stages, has been developed as a high-resolution expansion of the existing Edinburgh Mouse Atlas Project (EMAP) ontology. It also includes group terms for well-characterised structural and/or functional units comprising several sub-structures, such as the nephron and juxtaglomerular complex. Each term has been assigned a unique identification number. Synonyms have been used to improve the success of query searching and maintain wherever possible existing EMAP terms relating to this organ system. We describe here the principles and structure of the ontology and provide representative diagrammatic, histological, and whole mount and section RNA in situ hybridisation images to clarify the terms used within the ontology. Visual examples of how terms appear in different specimen types are also provided.en_US
dc.publisherElsevier BVen_US
dc.relation.ispartofjournalGene Expression Patternsen_US
dc.titleA high-resolution anatomical ontology of the developing murine genitourinary tracten_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2007 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.hasfulltextNo Full Text

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