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  • Impact of next-generation technologies on exploring socio-economically important parasites and developing new interventions

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    HofmannPUB172.pdf (426.7Kb)
    Author(s)
    Cantacessi, Cinzia
    Hofmann, Andreas
    Campbell, Bronwyn E
    Gasser, Robin B
    Griffith University Author(s)
    Hofmann, Andreas
    Year published
    2015
    Metadata
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    Abstract
    High-throughput molecular and computer technologies have become instrumental for systems biological explorations of pathogens, including parasites. For instance, investigations of the transcriptomes of different developmental stages of parasitic nematodes give insights into gene expression, regulation and function in a parasite, which is a significant step to understanding their biology, as well as interactions with their host(s) and disease. This chapter (1) gives a background on some key parasitic nematodes of socioeconomic importance, (2) describes sequencing and bioinformatic technologies for large-scale studies of the ...
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    High-throughput molecular and computer technologies have become instrumental for systems biological explorations of pathogens, including parasites. For instance, investigations of the transcriptomes of different developmental stages of parasitic nematodes give insights into gene expression, regulation and function in a parasite, which is a significant step to understanding their biology, as well as interactions with their host(s) and disease. This chapter (1) gives a background on some key parasitic nematodes of socioeconomic importance, (2) describes sequencing and bioinformatic technologies for large-scale studies of the transcriptomes and genomes of these parasites, (3) provides some recent examples of applications and (4) emphasizes the prospects of fundamental biological explorations of parasites using these technologies for the development of new interventions to combat parasitic diseases.
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    Book Title
    Veterinary Infection Biology: Molecular Diagnostics and High-Throughput Strategies, Methods in Molecular Biology
    Volume
    1247
    DOI
    https://doi.org/10.1007/978-1-4939-2004-4_31
    Copyright Statement
    © 2015 Springer. This is the author-manuscript version of this paper. It is reproduced here in accordance with the copyright policy of the publisher. Please refer to the publisher’s website for further information.
    Subject
    Medical Parasitology
    Other Chemical Sciences
    Biochemistry and Cell Biology
    Publication URI
    http://hdl.handle.net/10072/152430
    Collection
    • Book chapters

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