dc.contributor.author | Clemen, Christoph S | |
dc.contributor.author | Marko, Marija | |
dc.contributor.author | Strucksberg, Karl-Heinz | |
dc.contributor.author | Behrens, Juliane | |
dc.contributor.author | Wittig, Ilka | |
dc.contributor.author | Gaertner, Linda | |
dc.contributor.author | Winter, Lilli | |
dc.contributor.author | Chevessier, Frederic | |
dc.contributor.author | Matthias, Jan | |
dc.contributor.author | Tuerk, Matthias | |
dc.contributor.author | Tangavelou, Karthikeyan | |
dc.contributor.author | Schuetz, Johanna | |
dc.contributor.author | Arhzaouy, Khalid | |
dc.contributor.author | Klopffleisch, Karsten | |
dc.contributor.author | Hanisch, Franz-Georg | |
dc.contributor.author | Rottbauer, Wolfgang | |
dc.contributor.author | Bluemcke, Ingmar | |
dc.contributor.author | Just, Steffen | |
dc.contributor.author | Eichinger, Ludwig | |
dc.contributor.author | Hofmann, Andreas | |
dc.contributor.author | Schroeder, Rolf | |
dc.date.accessioned | 2017-06-05T01:53:32Z | |
dc.date.available | 2017-06-05T01:53:32Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0006-291X | |
dc.identifier.doi | 10.1016/j.bbrc.2015.06.086 | |
dc.identifier.uri | http://hdl.handle.net/10072/152474 | |
dc.description.abstract | Protein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.relation.ispartofpagefrom | 1210 | |
dc.relation.ispartofpageto | 1217 | |
dc.relation.ispartofjournal | Biochemical and Biophysical Research Communications | |
dc.relation.ispartofvolume | 463 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Medical biochemistry and metabolomics | |
dc.subject.fieldofresearch | Medical parasitology | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 3205 | |
dc.subject.fieldofresearchcode | 320704 | |
dc.title | VCP and PSMF1: antagonistic regulators of proteasome activity | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Hofmann, Andreas | |