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dc.contributor.authorClemen, Christoph S
dc.contributor.authorMarko, Marija
dc.contributor.authorStrucksberg, Karl-Heinz
dc.contributor.authorBehrens, Juliane
dc.contributor.authorWittig, Ilka
dc.contributor.authorGaertner, Linda
dc.contributor.authorWinter, Lilli
dc.contributor.authorChevessier, Frederic
dc.contributor.authorMatthias, Jan
dc.contributor.authorTuerk, Matthias
dc.contributor.authorTangavelou, Karthikeyan
dc.contributor.authorSchuetz, Johanna
dc.contributor.authorArhzaouy, Khalid
dc.contributor.authorKlopffleisch, Karsten
dc.contributor.authorHanisch, Franz-Georg
dc.contributor.authorRottbauer, Wolfgang
dc.contributor.authorBluemcke, Ingmar
dc.contributor.authorJust, Steffen
dc.contributor.authorEichinger, Ludwig
dc.contributor.authorHofmann, Andreas
dc.contributor.authorSchroeder, Rolf
dc.date.accessioned2017-06-05T01:53:32Z
dc.date.available2017-06-05T01:53:32Z
dc.date.issued2015
dc.identifier.issn0006-291X
dc.identifier.doi10.1016/j.bbrc.2015.06.086
dc.identifier.urihttp://hdl.handle.net/10072/152474
dc.description.abstractProtein turnover and quality control by the proteasome is of paramount importance for cell homeostasis. Dysfunction of the proteasome is associated with aging processes and human diseases such as neurodegeneration, cardiomyopathy, and cancer. The regulation, i.e. activation and inhibition of this fundamentally important protein degradation system, is still widely unexplored. We demonstrate here that the evolutionarily highly conserved type II triple-A ATPase VCP and the proteasome inhibitor PSMF1/PI31 interact directly, and antagonistically regulate proteasomal activity. Our data provide novel insights into the regulation of proteasomal activity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1210
dc.relation.ispartofpageto1217
dc.relation.ispartofjournalBiochemical and Biophysical Research Communications
dc.relation.ispartofvolume463
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical biochemistry and metabolomics
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3205
dc.subject.fieldofresearchcode320704
dc.titleVCP and PSMF1: antagonistic regulators of proteasome activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2015, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas


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