Show simple item record

dc.contributor.authorStroehlein, Andreas J
dc.contributor.authorYoung, Neil D
dc.contributor.authorJex, Aaron R
dc.contributor.authorSternberg, Paul W
dc.contributor.authorTan, Patrick
dc.contributor.authorBoag, Peter R
dc.contributor.authorHofmann, Andreas
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-08-31T02:18:50Z
dc.date.available2017-08-31T02:18:50Z
dc.date.issued2015
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep17759
dc.identifier.urihttp://hdl.handle.net/10072/152477
dc.description.abstractThe blood fluke Schistosoma haematobium causes urogenital schistosomiasis, a neglected tropical disease (NTD) that affects more than 110 million people. Treating this disease by targeted or mass administration with a single chemical, praziquantel, carries the risk that drug resistance will develop in this pathogen. Therefore, there is an imperative to search for new drug targets in S. haematobium and other schistosomes. In this regard, protein kinases have potential, given their essential roles in biological processes and as targets for drugs already approved by the US Food and Drug Administration (FDA) for use in humans. In this context, we defined here the kinome of S. haematobium using a refined bioinformatic pipeline. We classified, curated and annotated predicted kinases, and assessed the developmental transcription profiles of kinase genes. Then, we prioritised a panel of kinases as potential drug targets and inferred chemicals that bind to them using an integrated bioinformatic pipeline. Most kinases of S. haematobium are very similar to those of its congener, S. mansoni, offering the prospect of designing chemicals that kill both species. Overall, this study provides a global insight into the kinome of S. haematobium and should assist the repurposing or discovery of drugs against schistosomiasis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeLondon
dc.relation.ispartofpagefrom17759-1
dc.relation.ispartofpageto17759-15
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume5
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchcode320704
dc.titleDefining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record