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dc.contributor.authorFraenkel, Daviden_US
dc.contributor.authorRickard, Claireen_US
dc.contributor.authorThomas, Peteren_US
dc.contributor.authorFaoagali, Joanen_US
dc.contributor.authorGeorge, Narelleen_US
dc.contributor.authorWare, Robert S.en_US
dc.date.accessioned2017-05-03T15:25:04Z
dc.date.available2017-05-03T15:25:04Z
dc.date.issued2006en_US
dc.date.modified2009-01-12T06:23:17Z
dc.identifier.issn0090-3493en_US
dc.identifier.urihttp://hdl.handle.net/10072/15306
dc.description.abstractOBJECTIVE: Central venous catheters are the predominant cause of nosocomial bacteremia; however, the effectiveness of different antimicrobial central venous catheters remains uncertain. We compared the infection rate of silver-platinum-carbon (SPC)-impregnated catheters with rifampicin-minocycline (RM)-coated catheters. DESIGN: A large, single-center, prospective randomized study. SETTING: Twenty-two-bed adult general intensive care unit in a large tertiary metropolitan hospital in Brisbane, Australia (2000-2001). PATIENTS: Consecutive series of all central venous catheterizations in intensive care unit patients. INTERVENTIONS: Randomization, concealment, and blinding were carefully performed. Catheter insertion and care were performed according to published guidelines. Blood cultures were taken at central venous catheter removal, and catheter-tip cultures were performed by both roll-plate and sonication techniques. Pulsed field gel electrophoresis was used to establish shared clonal origin for matched isolates. MEASUREMENTS AND MAIN RESULTS: Central venous catheter colonization and catheter-related bloodstream infection were determined with a blinded technique using the evaluation of the extensive microbiological and clinical data collected and a rigorous classification system. Six hundred forty-six central venous catheters (RM 319, SPC 327) were inserted, and 574 (89%) were microbiologically evaluable. Colonization rates were lower for the RM catheters than SPC catheters (25 of 280, 8.9%; 43 of 294, 14.6%; p=.039). A Kaplan-Meier analysis that included catheter time in situ did not quite achieve statistical significance (p=.055). Catheter-related bloodstream infection was infrequent for both catheter-types (RM 4, 1.4%; SPC 5, 1.7%). CONCLUSIONS: The SPC catheter is a clinically effective antimicrobial catheter; however, the RM catheter had a lower colonization rate. Both catheter types had low rates of catheter-related bloodstream infection. These results indicate that future studies will require similar rigorous methodology and thousands of central venous catheters to demonstrate differences in catheter-related bloodstream infection rates.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherLippincott Wilkins & Williamsen_US
dc.publisher.placeUSAen_US
dc.publisher.urihttp://www.ccmjournal.org/pt/re/ccm/home.htm;jsessionid=HcfB2x2dY5dhlGyrJzGL12r2bdSTs51cKZBcnJS6Lp6668MTnGY7!1071114923!181195629!8091!-1en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom668en_US
dc.relation.ispartofpageto675en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalCritical Care Medicineen_US
dc.relation.ispartofvolume34en_US
dc.rights.retentionNen_AU
dc.subject.fieldofresearchcode321103en_US
dc.subject.fieldofresearchcode321009en_US
dc.titleA prospective randomized trial of rifampicin-minocycline coated and silver-platinum-carbon impregnated central venous cathetersen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2006 Lippincott, Williams & Wilkins. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.en_AU
gro.date.issued2006
gro.hasfulltextNo Full Text


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