The Outcomes and Treatment Burden of Childhood Acute Myeloid Leukaemia In Australia, 1997-2008: A Report From The Australian Paediatric Cancer Registry
Author(s)
Foresto, Steven A
Youlden, Danny R
Baade, Peter D
Hallahan, Andrew R
Aitken, Joanne F
Moore, Andrew S
Year published
2015
Metadata
Show full item recordAbstract
Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single‐centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997–2002) to 69.2% (2003–2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood ...
View more >Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single‐centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997–2002) to 69.2% (2003–2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood cancer diagnoses yet 7.9% of all childhood cancer mortality. Furthermore, treatment was associated with significant toxicity requiring intensive use of local health resources. Novel therapeutic strategies aimed at improving survival and reducing toxicity are urgently required.
View less >
View more >Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single‐centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997–2002) to 69.2% (2003–2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood cancer diagnoses yet 7.9% of all childhood cancer mortality. Furthermore, treatment was associated with significant toxicity requiring intensive use of local health resources. Novel therapeutic strategies aimed at improving survival and reducing toxicity are urgently required.
View less >
Journal Title
Pediatric Blood & Cancer
Volume
62
Issue
9
Subject
Clinical sciences
Oncology and carcinogenesis
Oncology and carcinogenesis not elsewhere classified