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  • The Outcomes and Treatment Burden of Childhood Acute Myeloid Leukaemia In Australia, 1997-2008: A Report From The Australian Paediatric Cancer Registry

    Author(s)
    Foresto, Steven A
    Youlden, Danny R
    Baade, Peter D
    Hallahan, Andrew R
    Aitken, Joanne F
    Moore, Andrew S
    Griffith University Author(s)
    Aitken, Joanne
    Baade, Peter D.
    Youlden, Danny R.
    Year published
    2015
    Metadata
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    Abstract
    Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single‐centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997–2002) to 69.2% (2003–2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood ...
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    Childhood acute myeloid leukaemia (AML) requires intensive therapy and is associated with survival rates that are substantially inferior to many other childhood malignancies. We undertook a retrospective analysis of Australian Paediatric Cancer Registry data from 1997 to 2008 together with a single‐centre audit during the same period assessing burden on service delivery at a tertiary children's hospital (Royal Children's Hospital, Brisbane). Although survival improved from 54.3% (1997–2002) to 69.2% (2003–2008), childhood AML caused a disproportionate number of childhood cancer deaths, accounting for 5.5% of all childhood cancer diagnoses yet 7.9% of all childhood cancer mortality. Furthermore, treatment was associated with significant toxicity requiring intensive use of local health resources. Novel therapeutic strategies aimed at improving survival and reducing toxicity are urgently required.
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    Journal Title
    Pediatric Blood & Cancer
    Volume
    62
    Issue
    9
    DOI
    https://doi.org/10.1002/pbc.25517
    Subject
    Clinical sciences
    Oncology and carcinogenesis
    Oncology and carcinogenesis not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/153847
    Collection
    • Journal articles

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