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dc.contributor.authorIvanovski, S.en_US
dc.contributor.authorHaase, H.en_US
dc.contributor.authorBartold, Marken_US
dc.date.accessioned2017-04-24T12:48:23Z
dc.date.available2017-04-24T12:48:23Z
dc.date.issued2001en_US
dc.date.modified2008-12-24T03:17:50Z
dc.identifier.issn00220345en_US
dc.identifier.urihttp://hdl.handle.net/10072/15419
dc.description.abstractThe successful regeneration of periodontal tissues is dependent, in part, on the ability of cells to reconstitute the mineralized tissues of cementum and bone. The aim of the present study was to characterize regeneration-associated cells in terms of their ability to express mineralized tissue macromolecules. Following guided tissue regeneration, cell cultures were established from regenerating tissue, periodontal ligament, and gingiva. Additionally, these cells were transfected, and single-cell-derived clones were established. Following treatment with platelet-derived growth factor-BB and insulin-derived growth factor-1, the presence of mRNA for alkaline phosphatase, osteocalcin, bone sialoprotein, osteopontin, and bone morphogenetic proteins-2 and -4 was assessed. The three cell types expressed similar mRNA levels for alkaline phosphatase, bone morphogenetic protein-2, and bone morphogenetic protein-4, whereas the expression of osteopontin, osteocalcin, and bone sialoprotein was greater in the periodontal ligament and regenerating tissue fibroblasts compared with the gingival fibroblasts. The two growth factors did not affect the expression of any of the genes. This study has identified markers that correlate with the known ability of periodontal ligament and regenerating tissue-derived fibroblasts to facilitate regeneration of the mineralized tissues of the periodontium.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent15579511 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherInternational Association for Dental Researchen_US
dc.publisher.placeUSen_US
dc.publisher.urihttp://jdr.iadrjournals.org/en_AU
dc.relation.ispartofpagefrom1665en_US
dc.relation.ispartofpageto1671en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalJournal of Dental Researchen_US
dc.relation.ispartofvolume80en_US
dc.subject.fieldofresearchcode320899en_US
dc.titleExpression of bone matrix protein mRNAs by primary and cloned cultures of the regenerative phenotype of human periodontal fibroblastsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2001 International & American Associations for Dental Research (IADR/AADR). The attached file is reproduced here in accordance with the copyright policy of the publisher. Use hypertext link for access to journal's website.en_AU
gro.date.issued2001
gro.hasfulltextFull Text


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