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dc.contributor.authorW. Remmerbach, Torsten
dc.contributor.authorWeidenbach, Horst
dc.contributor.authorHemprich, Alexander
dc.contributor.authorBocking, Alfred
dc.date.accessioned2017-05-03T15:18:43Z
dc.date.available2017-05-03T15:18:43Z
dc.date.issued2003
dc.identifier.issn09218912
dc.identifier.urihttp://hdl.handle.net/10072/15440
dc.description.abstractOBJECTIVE: We describe four patients presenting early oral cancers, detected cytologically on non-invasive brush biopsies including DNA-image cytometry as an adjunctive method before histology on scalpel biopsies confirmed the evidence of malignancy. METHODS: Brush biopsies were performed and smears thereof investigated cytologically. After Feulgen restaining, DNA-measurements were performed using a DNA-Image-Cytometer. CASE REPORTS: Oral squamous cell carcinomas were diagnosed cytologically in macroscopically suspicious lesions and malignancy confirmed by DNA-cytometry. The initially performed scalpel biopsies did neither supply evidence of oral cancer nor of severe dysplasia. After at least one to 15 months the occurrence of cancer was finally proven histologically on a second scalpel biopsy each (three microinvasive and one in situ carcinoma). CONCLUSION: Non-invasive brush biopsies are a suitable instrument for early cytologic detection of cancer of the mouth. DNA-image-cytometry, as an adjunctive method, can be used to confirm the cytologic diagnosis or suspicion of cancer in patients with doubtful lesions (dysplasias). DNA-aneuploidy is a marker for (prospective) malignancy in smears of the oral cavity, which may detect malignancy months prior to histology. In future this method could be used as a mass screening tool in dentists practice.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherIOS Press
dc.publisher.placeNetherlands
dc.publisher.urihttp://content.iospress.com/articles/analytical-cellular-pathology/acp242
dc.relation.ispartofpagefrom159
dc.relation.ispartofpageto166
dc.relation.ispartofissue4
dc.relation.ispartofjournalAnalytical Cellular Pathology
dc.relation.ispartofvolume25
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1112
dc.titleEarliest detection of oral cancer using non-invasive brush biopsy including DNA-image-cytometry: report on four cases
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-11T05:36:09Z
gro.hasfulltextNo Full Text
gro.griffith.authorRemmerbach, Torsten W.


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