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  • A genome screen for multiple sclerosis in Italian families

    Author(s)
    Broadley, S
    Sawcer, S
    D'Alfonso, S
    Hensiek, A
    Coraddu, F
    Gray, J
    Roxburgh, R
    Clayton, D
    Buttinelli, C
    Quattrone, A
    Trojano, M
    Massacesi, L
    Compston, A
    Griffith University Author(s)
    Broadley, Simon
    Year published
    2001
    Metadata
    Show full item record
    Abstract
    We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to ...
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    We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.
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    Journal Title
    Genes and Immunity
    Volume
    2
    Issue
    4
    Subject
    Immunology
    Publication URI
    http://hdl.handle.net/10072/15460
    Collection
    • Journal articles

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