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dc.contributor.authorR. Merriman, Terryen_US
dc.contributor.authorJ. Cordell, Heatheren_US
dc.contributor.authorA. Eaves, Iainen_US
dc.contributor.authorA. Danoy, Patricken_US
dc.contributor.authorCoraddu, Francescaen_US
dc.contributor.authorBarber, Rachaelen_US
dc.contributor.authorCucca, Francescoen_US
dc.contributor.authorBroadley, Simonen_US
dc.contributor.authorSawcer, Stephenen_US
dc.contributor.authorCompston, Alastairen_US
dc.contributor.authorWordsworth, Paulen_US
dc.contributor.authorShatford, Janeen_US
dc.contributor.authorLaval, Steveen_US
dc.contributor.authorJirholt, Johanen_US
dc.contributor.authorHolmdahl, Rikarden_US
dc.contributor.authorN. Theofilopoulos, Argyriosen_US
dc.contributor.authorH. Kono, Dwighten_US
dc.contributor.authorTuomilehto, Jaakoen_US
dc.contributor.authorTuomilehto-Wolf, Evaen_US
dc.contributor.authorBuzzetti, Raffaellaen_US
dc.contributor.authorMarrosu, Maria Giovannaen_US
dc.contributor.authorE. Undlien, Dagen_US
dc.contributor.authorS. Ronningen, Kjerstien_US
dc.contributor.authorIonesco-Tirgoviste, C.en_US
dc.contributor.authorP. Shield, Julianen_US
dc.contributor.authorPociot, Flemingen_US
dc.contributor.authorNerup, Jornen_US
dc.contributor.authorO. Jacob, Chaimen_US
dc.contributor.authorPolychronakos, Constantinen_US
dc.contributor.authorC. Bain, Steveen_US
dc.contributor.authorA. Todd, Johnen_US
dc.description.abstractSome immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a genetic association with the major histocompatibility complex. We have previously published evidence, from 1,708 families, for linkage and association of a haplotype of three markers in the D18S487 region of chromosome 18q21 with type 1 diabetes. Here, the three markers were typed in an independent set of 627 families and, although there was evidence for linkage (maximum logarithm of odds score [MLS] = 1.2; P = 0.02), no association was detected. Further linkage analysis revealed suggestive evidence for linkage of chromosome 18q21 to type 1 diabetes in 882 multiplex families (MLS = 2.2; lambdas = 1.2; P = 0.001), and by meta-analysis the orthologous region (also on chromosome 18) is linked to diabetes in rodents (P = 9 x 10(-4)). By meta-analysis, both human chromosome 18q12-q21 and the rodent orthologous region show positive evidence for linkage to an autoimmune phenotype (P = 0.004 and 2 x 10(-8), respectively, empirical P = 0.01 and 2 x 10(-4), respectively). In the diabetes-linked region of chromosome 18q12-q21, a candidate gene, deleted in colorectal carcinoma (DCC), was tested for association with human autoimmunity in 3,380 families with type 1 diabetes, MS, and RA. A haplotype ("2-10") of two newly characterized microsatellite markers within DCC showed evidence for association with autoimmunity (P = 5 x 10(-6)). Collectively, these data suggest that a locus (or loci) exists on human chromosome 18q12-q21 that influences multiple autoimmune diseases and that this association might be conserved between species.en_US
dc.publisherAmerican Diabetes Associationen_US
dc.titleSuggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseasesen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.hasfulltextNo Full Text

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