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dc.contributor.authorBerners-Price, Sueen_US
dc.contributor.authorGalettis, P.en_US
dc.contributor.authorHealy, Peteren_US
dc.contributor.authorMcKeage, M.en_US
dc.date.accessioned2017-04-04T17:51:51Z
dc.date.available2017-04-04T17:51:51Z
dc.date.issued1999en_US
dc.date.modified2009-08-25T03:44:36Z
dc.identifier.issn00108545en_US
dc.identifier.doi10.1016/S0010-8545(99)00039-9en_AU
dc.identifier.urihttp://hdl.handle.net/10072/15550
dc.description.abstractThe 1:2 adducts of Ag(I) and Au(I) with 1,2-bis(di-n-pyridylphosphino)ethane (dnpype) for n=2, 3 and 4 have been synthesised and solution properties characterised by multinuclear NMR spectroscopy. The complexes are hydrophilic analogs of the lipophilic Au(I) antitumour complex [Au(dppe)2]+ and the degree of hydrophilicity depends critically on the position of the N atom in the pyridyl ring. The complexes of d3pype and d4pype are simple monomeric [M(d3pype)2]+ and [M(d4pype)2]+ species which have a much higher water solubility than the 2-pyridyl complexes which crystallise in the solid state as dimeric [{M(d2pype)2}2]2+. In solution these 1:2 M:d2pype species exist as equilibrium mixtures of monomeric, dimeric and trimeric (Ag) or tetrameric (Au) clusters. The Au(I) and Ag(I)pyridyl phosphine complexes have been evaluated for antitumour activity against a panel of cultured human ovarian carcinoma cell lines. The results show both potent and selective activity for the compounds with IC50 values ranging from 0.18 to 1500 卮 There is a correlation between the degree of antitumour selectivity and the octanol/water partition coefficients with the greatest selectivity (500-fold range) found for the most hydrophilic complex [Au(d4pype)2]Cl. Clinical development of the parent compound [Au(dppe)2]+ was halted by liver toxicity and the hydrophilic pyridylphosphine analogs are significantly less toxic than [Au(dppe)2]+ when exposed to isolated rat hepatocytes. Convenient synthetic routes to the bidentate pyridyl phosphines d2pype, d3pype and d4pype are also described.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Scienceen_US
dc.publisher.placeSwitzerlanden_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00108545en_AU
dc.relation.ispartofpagefrom823en_US
dc.relation.ispartofpageto836en_US
dc.relation.ispartofjournalCoordination Chemistry Reviewsen_US
dc.relation.ispartofvolume185-186en_US
dc.subject.fieldofresearchcode259999en_US
dc.titleStructural and Solution Chemistry of gold(I) and Silver(I) complexes of bidentate pyridyl phosphines: selective antitumour agentsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.rights.copyrightCopyright 1999 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued1999
gro.hasfulltextNo Full Text


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