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dc.contributor.authorChuah, Teong Lip
dc.contributor.authorWalker, David Gregory
dc.contributor.authorWei, Ming
dc.contributor.authorScott, Shaun
dc.contributor.authorLavin, Martin Francis
dc.date.accessioned2017-11-02T03:51:12Z
dc.date.available2017-11-02T03:51:12Z
dc.date.issued2012
dc.identifier.issn10196439
dc.identifier.doi10.3892/ijo.2012.1409
dc.identifier.urihttp://hdl.handle.net/10072/155969
dc.description.abstractGlioblastoma multiforme (GBM) is the most common primary brain tumour and extirpation followed by radio- and chemotherapy has had minimal impact on the median survival of patients which is still less than one year. Hence, a novel therapeutic modality is required if the survival of patients with this disease is to be improved. ATM, mutated in the human genetic disorder ataxia-telangiectasia (A-T), plays a central role in the response to DNA double strand breaks and patients with this disorder are characterised by extreme sensitivity to radiation, increased risk of cancer and neurodegeneration. Thus, ATM represents a potential target for radiosensitization of brain tumour cells. A safe, non-replicating lentivirus is used to abrogate ATM in GBM through the antisense and RNAi approaches for radiosensitization. With either techniques, ATM protein was reduced by >90% and there was a 3‑fold sensitization of GBM cells to radiation. ATM protein activation as well as ATM pS1981 foci formation were defective and downstream signalling determined by Ser15 phosphorylation on p53 was reduced. Success in the approaches provides a novel and exciting strategy for the treatment of GBM and thus improving the survival of patients with these tumours.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpandidos Publications
dc.publisher.placeGreece
dc.relation.ispartofpagefrom1963
dc.relation.ispartofpageto1969
dc.relation.ispartofissue6
dc.relation.ispartofjournalInternational Journal of Oncology
dc.relation.ispartofvolume40
dc.subject.fieldofresearchCancer Therapy (excl. Chemotherapy and Radiation Therapy)
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111204
dc.subject.fieldofresearchcode1112
dc.titleApproaches to sensitizing glioblastoma to radiotherapy: Use of lentiviral vectors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2011 Spandidos Publications. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the conference's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorWei, Ming Q.
gro.griffith.authorWalker, David G.


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