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dc.contributor.authorScott, Stacyen_US
dc.contributor.authorScott, Kenen_US
dc.contributor.authorBlanchard, Helenen_US
dc.date.accessioned2017-04-24T11:30:14Z
dc.date.available2017-04-24T11:30:14Z
dc.date.issued2007en_US
dc.identifier.issn17443091en_US
dc.identifier.doi10.1107/S1744309107050142en_US
dc.identifier.urihttp://hdl.handle.net/10072/16341
dc.description.abstractGalectin-1 is considered a regulator protein as it is ubiquitously expressed throughout the adult body and is responsible for a broad range of cellular regulatory functions. Interest in galectin-1 from a drug-design perspective is founded on evidence of its over-expression by many cancers, and its immunomodulatory properties. The development of galectin-1-specific inhibitors is a rational approach to the fight against cancer because although galectin-1 induces a plethora of effects, null mice appear normal. X-ray crystallographic structure determination will aid structure-based design of galectin-1 inhibitors. Herein the crystallization and preliminary diffraction analysis of human galectin-1 crystals, generated under six different conditions, is reported. X-ray diffraction data enabled assignment of unit cell parameters for crystals grown under one condition, belonging to a tetragonal crystal system, and definition of another as monoclinic P21, representing two new crystal forms of human galectin-1.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherInternational Union of Crystallographyen_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom967en_US
dc.relation.ispartofpageto971en_US
dc.relation.ispartofjournalActa Crystallographica. Section F: Structural Biology and Crystallization Communicationsen_US
dc.relation.ispartofvolumeF63en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode250302en_US
dc.titleCrystallisation and preliminary crystallographic analysis of recombinant human galectin-1en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2015-01-30T00:42:47Z
gro.hasfulltextNo Full Text


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