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  • Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility

    Author(s)
    Barberis, D
    Artigiani, S
    Casazza, A
    Corso, S
    Giordano, S
    Love, CA
    Jones, EY
    Comoglio, PM
    Tamagnone, L
    Griffith University Author(s)
    Love, Christopher A.
    Year published
    2004
    Metadata
    Show full item record
    Abstract
    Plexins encode receptors for semaphorins, molecular signals guiding cell migration, and axon pathfinding. The mechanisms mediating plexin function are poorly understood. Plexin activation in adhering cells rapidly leads to retraction of cellular processes and cell rounding "cell collapse"). Here we show that, unexpectedly, this response does not require the activity of Rho-dependent kinase (ROCK) nor the contraction of F-actin cables. Interestingly, integrin-based focal adhesive structures are disassembled within minutes upon plexin activation; this is followed by actin depolymerization and, eventually, by cellular collapse. ...
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    Plexins encode receptors for semaphorins, molecular signals guiding cell migration, and axon pathfinding. The mechanisms mediating plexin function are poorly understood. Plexin activation in adhering cells rapidly leads to retraction of cellular processes and cell rounding "cell collapse"). Here we show that, unexpectedly, this response does not require the activity of Rho-dependent kinase (ROCK) nor the contraction of F-actin cables. Interestingly, integrin-based focal adhesive structures are disassembled within minutes upon plexin activation; this is followed by actin depolymerization and, eventually, by cellular collapse. We also show that plexin activation hinders cell attachment to adhesive substrates, blocks the extension of lamellipodia, and thereby inhibits cell migration. We conclude that plexin signaling uncouples cell substrate-adhesion from cytoskeletal dynamics required for cell migration and axon extension.
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    Journal Title
    FASEB Journal
    Volume
    18
    Issue
    3
    Publisher URI
    http://www.fasebj.org/
    DOI
    https://doi.org/10.1096/fj.03-0957fje
    Copyright Statement
    © 2004 Federation of American Societies for Experimental Biology. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
    Subject
    Biochemistry and cell biology
    Zoology
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/16461
    Collection
    • Journal articles

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