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dc.contributor.authorHalstead, Scott B
dc.contributor.authorMahalingam, Suresh
dc.contributor.authorMarovich, Mary A
dc.contributor.authorUbol, Sukathida
dc.contributor.authorMosser, David M
dc.date.accessioned2018-09-11T06:16:03Z
dc.date.available2018-09-11T06:16:03Z
dc.date.issued2010
dc.identifier.issn1473-3099
dc.identifier.doi10.1016/S1473-3099(10)70166-3
dc.identifier.urihttp://hdl.handle.net/10072/165026
dc.description.abstractA wide range of microorganisms can replicate in macrophages, and cell entry of these pathogens via non-neutralising IgG antibody complexes can result in increased intracellular infection through idiosyncratic Fcγ-receptor signalling. The activation of Fcγ receptors usually leads to phagocytosis. Paradoxically, the ligation of monocyte or macrophage Fcγ receptors by IgG immune complexes, rather than aiding host defences, can suppress innate immunity, increase production of interleukin 10, and bias T-helper-1 (Th1) responses to Th2 responses, leading to increased infectious output by infected cells. This intrinsic antibody-dependent enhancement (ADE) of infection modulates the severity of diseases as disparate as dengue haemorrhagic fever and leishmaniasis. Intrinsic ADE is distinct from extrinsic ADE, whereby complexes of infectious agents with non-neutralising antibodies lead to an increased number of infected cells. Intrinsic ADE might be involved in many protozoan, bacterial, and viral infections. We review insights into intracellular mechanisms and implications of enhanced pathogenesis after ligation of macrophage Fcγ receptors by infectious immune complexes.
dc.languageEnglish
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom712
dc.relation.ispartofpageto722
dc.relation.ispartofissue10
dc.relation.ispartofjournalLancet Infectious Diseases
dc.relation.ispartofvolume10
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchMedical virology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode320705
dc.titleIntrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes
dc.typeJournal article
dc.type.descriptionU2 - Reviews/Reports
dc.type.codeD - Reviews/Reports
gro.hasfulltextNo Full Text
gro.griffith.authorMahalingam, Suresh


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