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  • Lipid-protein interactions: Lessons learned from stress

    Author(s)
    Battle, AR
    Ridone, P
    Bavi, N
    Nakayama, Y
    Nikolaev, YA
    Martinac, B
    Griffith University Author(s)
    Battle, Andrew
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Biological membranes are essential for normal function and regulation of cells, forming a physical barrier between extracellular and intracellular space and cellular compartments. These physical barriers are subject to mechanical stresses. As a consequence, nature has developed proteins that are able to transpose mechanical stimuli into meaningful intracellular signals. These proteins, termed Mechanosensitive (MS) proteins provide a variety of roles in response to these stimuli. In prokaryotes these proteins form transmembrane spanning channels that function as osmotically activated nanovalves to prevent cell lysis by ...
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    Biological membranes are essential for normal function and regulation of cells, forming a physical barrier between extracellular and intracellular space and cellular compartments. These physical barriers are subject to mechanical stresses. As a consequence, nature has developed proteins that are able to transpose mechanical stimuli into meaningful intracellular signals. These proteins, termed Mechanosensitive (MS) proteins provide a variety of roles in response to these stimuli. In prokaryotes these proteins form transmembrane spanning channels that function as osmotically activated nanovalves to prevent cell lysis by hypoosmotic shock. In eukaryotes, the function of MS proteins is more diverse and includes physiological processes such as touch, pain and hearing. The transmembrane portion of these channels is influenced by the physical properties such as charge, shape, thickness and stiffness of the lipid bilayer surrounding it, as well as the bilayer pressure profile. In this review we provide an overview of the progress to date on advances in our understanding of the intimate biophysical and chemical interactions between the lipid bilayer and mechanosensitive membrane channels, focusing on current progress in both eukaryotic and prokaryotic systems. These advances are of importance due to the increasing evidence of the role the MS channels play in disease, such as xerocytosis, muscular dystrophy and cardiac hypertrophy. Moreover, insights gained from lipid–protein interactions of MS channels are likely relevant not only to this class of membrane proteins, but other bilayer embedded proteins as well. This article is part of a Special Issue entitled: Lipid–protein interactions.
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    Journal Title
    Biochimica et Biophysica Acta. Biomembranes
    Volume
    1848
    Issue
    9
    DOI
    https://doi.org/10.1016/j.bbamem.2015.04.012
    Subject
    Biochemistry and cell biology
    Other biological sciences
    Other biological sciences not elsewhere classified
    Chemical engineering
    Publication URI
    http://hdl.handle.net/10072/166931
    Collection
    • Journal articles

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