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dc.contributor.authorA. Davis, Rohanen_US
dc.contributor.authorAalbersberg, Williamen_US
dc.contributor.authorMeo, Semisien_US
dc.contributor.authorda Rocha, Rosana Moreiraen_US
dc.contributor.authorM. Ireland, Chrisen_US
dc.date.accessioned2017-04-24T09:50:11Z
dc.date.available2017-04-24T09:50:11Z
dc.date.issued2002en_US
dc.date.modified2009-09-10T05:13:18Z
dc.identifier.issn00404020en_US
dc.identifier.doi10.1016/S0040-4020(02)00228-4en_AU
dc.identifier.urihttp://hdl.handle.net/10072/16734
dc.description.abstractChem. investigation of a Fijian ascidian, Polyandrocarpa sp., has resulted in the isolation of two new 2-aminoimidazolone-derived compds., polyandrocarpamines A (I) and B (II). The structures of these unique metabolites were detd. by the interpretation of spectroscopic data and confirmed by total synthesis. The stereospecific synthesis of I was accomplished using aldol condensation chem. to generate an arylidene thiohydantoin that was subsequently transaminated to yield polyandrocarpamine A. Demethylation of synthetic I afforded polyandrocarpamine B. Both the natural product and synthetic polyandrocarpamines were assigned Z geometries about the exocyclic double bond (C-5/C-7) on the basis of 13C/1H long-range coupling consts., which were measured using a gHSQMBC expt.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent98906 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/00404020en_AU
dc.relation.ispartofpagefrom3263en_US
dc.relation.ispartofpageto3269en_US
dc.relation.ispartofissue16en_US
dc.relation.ispartofjournalTetrahedronen_US
dc.relation.ispartofvolume58en_US
dc.subject.fieldofresearchcode250399en_US
dc.titleThe isolation and synthesis of polyandrocarpamines A and B. Two new 2-aminoimidazolone compounds from the Fijian ascidian, Polyandrocarpa sp.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2002 Elsevier. Please refer to the journal's website for access to the definitive, published version. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. "en_AU
gro.date.issued2002
gro.hasfulltextFull Text


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