Lissoclinotoxins E and F, novel cytotoxic alkaloids from a Philippine didemnid ascidian
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Bioassay-guided fractionation of the MeOH ext. from a Philippine didemnid ascidian resulted in the isolation of two new dimeric alkaloids, lissoclinotoxins E (I) and F (II). The polysulfide structures for compds. I and II were detd. by interpretation of spectroscopic data and chem. degrdn. Computational chem. studies suggested that the N-alkyl chains about the tricyclic systems of lissoclinotoxins E and F had trans and cis orientations, resp. Alkaloids I and II displayed IC50 values of 2.3 and 1.5 mg/mL, resp., towards the PTEN-deficient human breast carcinoma cell line, MDA-MB-468.
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