• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis

    Author(s)
    Azeem, Ayesha
    English, Andrew
    Kumar, Pramod
    Satyam, Abhigyan
    Biggs, Manus
    Jones, Eleanor
    Tripathi, Bhawana
    Basu, Nandita
    Henkel, Jan
    Vaquette, Cedryck
    Rooney, Niall
    Riley, Graham
    O'Riordan, Alan
    Cross, Graham
    Ivanovski, Saso
    Hutmacher, Dietmar
    Pandit, Abhay
    Zeugolis, Dimitrios
    Griffith University Author(s)
    Ivanovski, Saso
    Vaquette, Cedryck
    Hutmacher, Dietmar W.
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Aim: Topographically modified substrates are increasingly used in tissue engineering to enhance biomimicry. The overarching hypothesis is that topographical cues will control cellular response at the cell–substrate interface. Materials & methods: The influence of anisotropically ordered poly(lactic-co-glycolic acid) substrates (constant groove width of ˜1860 nm; constant line width of ˜2220 nm; variable groove depth of ˜35, 306 and 2046 nm) on in vitro and in vivo osteogenesis were assessed. Results & discussion: We demonstrate that substrates with groove depths of approximately 306 and 2046 nm promote osteoblast alignment ...
    View more >
    Aim: Topographically modified substrates are increasingly used in tissue engineering to enhance biomimicry. The overarching hypothesis is that topographical cues will control cellular response at the cell–substrate interface. Materials & methods: The influence of anisotropically ordered poly(lactic-co-glycolic acid) substrates (constant groove width of ˜1860 nm; constant line width of ˜2220 nm; variable groove depth of ˜35, 306 and 2046 nm) on in vitro and in vivo osteogenesis were assessed. Results & discussion: We demonstrate that substrates with groove depths of approximately 306 and 2046 nm promote osteoblast alignment parallel to underlined topography in vitro. However, none of the topographies assessed promoted directional osteogenesis in vivo. Conclusion: 2D imprinting technologies are useful tools for in vitro cell phenotype maintenance.
    View less >
    Journal Title
    Nanomedicine
    Volume
    10
    Issue
    5
    DOI
    https://doi.org/10.2217/nnm.14.218
    Subject
    Physical chemistry
    Medical biotechnology
    Nanotechnology
    Periodontics
    Publication URI
    http://hdl.handle.net/10072/167369
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander