Show simple item record

dc.contributor.authorAzeem, Ayesha
dc.contributor.authorEnglish, Andrew
dc.contributor.authorKumar, Pramod
dc.contributor.authorSatyam, Abhigyan
dc.contributor.authorBiggs, Manus
dc.contributor.authorJones, Eleanor
dc.contributor.authorTripathi, Bhawana
dc.contributor.authorBasu, Nandita
dc.contributor.authorHenkel, Jan
dc.contributor.authorVaquette, Cedryck
dc.contributor.authorRooney, Niall
dc.contributor.authorRiley, Graham
dc.contributor.authorO'Riordan, Alan
dc.contributor.authorCross, Graham
dc.contributor.authorIvanovski, Saso
dc.contributor.authorHutmacher, Dietmar
dc.contributor.authorPandit, Abhay
dc.contributor.authorZeugolis, Dimitrios
dc.date.accessioned2018-06-15T01:17:54Z
dc.date.available2018-06-15T01:17:54Z
dc.date.issued2015
dc.identifier.issn1743-5889
dc.identifier.doi10.2217/nnm.14.218
dc.identifier.urihttp://hdl.handle.net/10072/167369
dc.description.abstractAim: Topographically modified substrates are increasingly used in tissue engineering to enhance biomimicry. The overarching hypothesis is that topographical cues will control cellular response at the cell–substrate interface. Materials & methods: The influence of anisotropically ordered poly(lactic-co-glycolic acid) substrates (constant groove width of ˜1860 nm; constant line width of ˜2220 nm; variable groove depth of ˜35, 306 and 2046 nm) on in vitro and in vivo osteogenesis were assessed. Results & discussion: We demonstrate that substrates with groove depths of approximately 306 and 2046 nm promote osteoblast alignment parallel to underlined topography in vitro. However, none of the topographies assessed promoted directional osteogenesis in vivo. Conclusion: 2D imprinting technologies are useful tools for in vitro cell phenotype maintenance.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFuture Medicine
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom693
dc.relation.ispartofpageto711
dc.relation.ispartofissue5
dc.relation.ispartofjournalNanomedicine
dc.relation.ispartofvolume10
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode4018
dc.subject.fieldofresearchcode320310
dc.titleThe influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorIvanovski, Saso
gro.griffith.authorVaquette, Cedryck
gro.griffith.authorHutmacher, Dietmar W.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record