Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp.

Feng, YJ; Blunt, JW; Cole, ALJ; Cannon, JF; Robinson, WT; Munro, MHG

doi:10.1021/jo0263059

Author(s)

Feng, YJ

Blunt, JW

Cole, ALJ

Cannon, JF

Robinson, WT

Munro, MHG

Griffith University Author(s)

Feng, Yun J.

Year published

2003

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Abstract

Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.
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Journal Title

Journal of Organic Chemistry

Volume

Issue

Publisher URI

http://pubs.acs.org/journal/joceah

DOI

https://doi.org/10.1021/jo0263059

Copyright Statement

Subject

Medicinal and biomolecular chemistry

Organic chemistry

Publication URI

http://hdl.handle.net/10072/16749

Collection

Journal articles