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  • Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp.

    Author(s)
    Feng, YJ
    Blunt, JW
    Cole, ALJ
    Cannon, JF
    Robinson, WT
    Munro, MHG
    Griffith University Author(s)
    Feng, Yun J.
    Year published
    2003
    Metadata
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    Abstract
    Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.
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    Journal Title
    Journal of Organic Chemistry
    Volume
    68
    Issue
    5
    Publisher URI
    http://pubs.acs.org/journal/joceah
    DOI
    https://doi.org/10.1021/jo0263059
    Copyright Statement
    © 2003 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Use hypertext link above to access the ACS website.
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Publication URI
    http://hdl.handle.net/10072/16749
    Collection
    • Journal articles

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