Two novel cytotoxic cyclodepsipeptides from a mycoparasitic Cladobotryum sp.

Feng, Yunjiang; W. Blunt, John; L. J. Cole, Anthony; F. Cannon, John; T. Robinson, Ward; H. G. Munro, Murray

doi:10.1021/jo0263059

Author

Year published

2003

Metadata

Show full item record

Abstract

Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.Two novel cyclodepsipeptides (1 and 2) along with three known compounds (3-5) were isolated from a New Zealand isolate of a Cladobotryum sp. The structures of 1 and 2 were elucidated from NMR and HRESIMS experiments, and the absolute stereochemistry of 2 was established by X-ray crystallography and chemical degradation. Compounds 1 and 2 were both cytotoxic against murine P388 leukemia cells.
View less >

Journal Title

Journal of Organic Chemistry

Volume

Issue

Publisher URI

http://pubs.acs.org/journal/joceah

DOI

https://doi.org/10.1021/jo0263059

Copyright Statement

Publication URI

http://hdl.handle.net/10072/16749

Collection

Journal articles