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  • Heat shock response and homeostatic plasticity

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    Author(s)
    Karunanithi, Shanker
    Brown, Ian R.
    Griffith University Author(s)
    Karunanithi, Shanker
    Year published
    2015
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    Abstract
    Heat shock response and homeostatic plasticity are mechanisms that afford functional stability to cells in the face of stress. Each mechanism has been investigated independently, but the link between the two has not been extensively explored. We explore this link. The heat shock response enables cells to adapt to stresses such as high temperature, metabolic stress and reduced oxygen levels. This mechanism results from the production of heat shock proteins (HSPs) which maintain normal cellular functions by counteracting the misfolding of cellular proteins. Homeostatic plasticity enables neurons and their target cells to ...
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    Heat shock response and homeostatic plasticity are mechanisms that afford functional stability to cells in the face of stress. Each mechanism has been investigated independently, but the link between the two has not been extensively explored. We explore this link. The heat shock response enables cells to adapt to stresses such as high temperature, metabolic stress and reduced oxygen levels. This mechanism results from the production of heat shock proteins (HSPs) which maintain normal cellular functions by counteracting the misfolding of cellular proteins. Homeostatic plasticity enables neurons and their target cells to maintain their activity levels around their respective set points in the face of stress or disturbances. This mechanism results from the recruitment of adaptations at synaptic inputs, or at voltage-gated ion channels. In this perspective, we argue that heat shock triggers homeostatic plasticity through the production of HSPs. We also suggest that homeostatic plasticity is a form of neuroprotection.
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    Journal Title
    Frontiers in Cellular Neuroscience
    Volume
    9
    DOI
    https://doi.org/10.3389/fncel.2015.00068
    Copyright Statement
    © 2015 Karunanithi and Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Animal Neurobiology
    Cellular Nervous System
    Neurosciences not elsewhere classified
    Biochemistry and Cell Biology
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/167619
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    • Journal articles

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