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dc.contributor.authorDissanayake, U
dc.contributor.authorJohnson, NW
dc.contributor.authorWarnakulasuriya, KAAS
dc.contributor.editorC Sarraf, Dr Sasaki, Z Darzynkiewics
dc.date.accessioned2019-02-27T22:43:57Z
dc.date.available2019-02-27T22:43:57Z
dc.date.issued2003
dc.date.modified2008-02-14T08:23:28Z
dc.identifier.issn0960-7722
dc.identifier.doi10.1046/j.1365-2184.2003.00282.x
dc.identifier.urihttp://hdl.handle.net/10072/16880
dc.description.abstractThe cell proliferation status of 60 oral squamous cell carcinomas from Sri Lankan subjects was examined by immunohistochemistry using the Ki-67 index. A comparison was made between the indices derived from the centre of the tumours and those derived from the invasive fronts of the same tumours. There was a positive correlation between the two indices suggesting a clonal expansion of malignant cells, but the mean index derived for the invasive fronts (29.75 11.64) was significantly higher than the mean index for the body of these tumours (25.65 11.64). Thus, at a given time, more peripheral cells at the invasive front are proliferating and this compartment is likely to be more informative in prognostic and other behavioural studies involving the cell cycle. In squamous carcinomas, increased and uncontrolled cell proliferation at the invasive front may be one feature contributory to the invasion.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom255
dc.relation.ispartofpageto264
dc.relation.ispartofissue5
dc.relation.ispartofjournalCell Proliferation
dc.relation.ispartofvolume36
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode3101
dc.titleComparison of cell proliferation in the centre and advancing fronts of oral squamous cell carcinomas using Ki-67 index
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2003
gro.hasfulltextNo Full Text
gro.griffith.authorJohnson, Newell W.


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