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dc.contributor.authorGardiner, Ren_US
dc.contributor.authorGreen, H.en_US
dc.contributor.authorHeadley, B.en_US
dc.contributor.authorMactaggart, P.en_US
dc.contributor.authorNicol, D.en_US
dc.contributor.authorPakenham, K.en_US
dc.contributor.authorSwanson, C.en_US
dc.contributor.authorWatson, R.en_US
dc.contributor.authorYaxley, J.en_US
dc.date.accessioned2017-04-04T20:58:16Z
dc.date.available2017-04-04T20:58:16Z
dc.date.issued2004en_US
dc.date.modified2009-11-10T05:53:46Z
dc.identifier.issn1464-4096en_US
dc.identifier.doi10.1111/j.1464-410X.2004.04763.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/16906
dc.description.abstractOBJECTIVES To investigate the effects of different management strategies for non-localized prostate cancer on men's quality of life and cognitive functioning. PATIENTS, SUBJECTS AND METHODS Men with prostate cancer were randomly assigned to one of four treatment arms: leuprorelin, goserelin, cyproterone acetate (CPA), or close clinical monitoring. In a repeated-measures design, men were assessed before treatment (baseline) and after 6 and 12 months of treatment. A community comparison group of men of the same age with no prostate cancer participated for the same length of time. The men were recruited from public and private urology departments from university teaching hospitals. All those with prostate cancer who were eligible for hormonal therapy had no symptoms requiring immediate therapy. In all, 82 patients were randomized and 62 completed the 1-year study, and of the 20 community participants, 15 completed the study. The main outcome measures were obtained from questionnaires on emotional distress, existential satisfaction, physical function and symptoms, social and role function, subjective cognitive function, and sexual function, combined with standard neuropsychological tests of memory, attention, and executive functions. RESULTS Sexual dysfunction increased for patients on androgen-suppressing therapies, and emotional distress increased in those assigned to CPA or close clinical monitoring. Compared with before treatment there was evidence of an adverse effect of leuprorelin, goserelin, and CPA on cognitive function. Conclusions In deciding the timing of androgen suppression therapy for prostate cancer, consideration should be given to potential adverse effects on quality of life and cognitive function.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent142207 bytes
dc.format.extent26553 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishingen_US
dc.publisher.placeDublinen_US
dc.publisher.urihttp://www.blackwellpublishing.com/en_AU
dc.relation.ispartofpagefrom975en_US
dc.relation.ispartofpageto979en_US
dc.relation.ispartofissue4en_AU
dc.relation.ispartofjournalBJU Internationalen_US
dc.relation.ispartofvolume93en_US
dc.subject.fieldofresearchcode380103en_US
dc.subject.fieldofresearchcode321029en_US
dc.subject.fieldofresearchcode380107en_US
dc.titleQuality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: A randomized controlled trialen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2004 Blackwell Publishing. This is the author-manuscript version of the paper. Reproduced in accordance with the copyright policy of the publisher. The definitive version is available at www.blackwell-synergy.comen_AU
gro.date.issued2004
gro.hasfulltextFull Text


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