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dc.contributor.authorLiu, JW
dc.contributor.authorLewohl, JM
dc.contributor.authorDodd, PR
dc.contributor.authorRandall, PK
dc.contributor.authorHarris, RA
dc.contributor.authorMayfield, RD
dc.date.accessioned2017-05-03T11:36:56Z
dc.date.available2017-05-03T11:36:56Z
dc.date.issued2004
dc.date.modified2008-02-14T08:24:36Z
dc.identifier.issn0022-3042
dc.identifier.urihttp://hdl.handle.net/10072/16911
dc.description.abstractChronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence. This results, at least partially, from neural adaptations at a cellular level. Previous genome-wide gene expression studies using pooled human brain samples showed that alcohol abuse causes widespread changes in the pattern of gene expression in the frontal and motor cortices of human brain. Because these studies used pooled samples, they could not determine variability between different individuals. In the present study, we profiled gene expression levels of 14 postmortem human brains (seven controls and seven alcoholic cases) using cDNA microarrays (46 448 clones per array). Both frontal cortex and motor cortex brain regions were studied. The list of genes differentially expressed confirms and extends previous studies of alcohol responsive genes. Genes identified as differentially expressed in two brain regions fell generally into similar functional groups, including metabolism, immune response, cell survival, cell communication, signal transduction and energy production. Importantly, hierarchical clustering of differentially expressed genes accurately distinguished between control and alcoholic cases, particularly in the frontal cortex.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherBlackwell Publishing Ltd
dc.publisher.placeOxford, UK
dc.relation.ispartofpagefrom1050
dc.relation.ispartofpageto1058
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Neurochemistry
dc.relation.ispartofvolume90
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1109
dc.titleGene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2004
gro.hasfulltextNo Full Text
gro.griffith.authorLewohl, Joanne M.
gro.griffith.authorDodd, Peter


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