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dc.contributor.authorMayfield, RD
dc.contributor.authorLewohl, JM
dc.contributor.authorDodd, PR
dc.contributor.authorHerlihy, A
dc.contributor.authorLiu, JW
dc.contributor.authorHarris, RA
dc.date.accessioned2017-05-03T11:36:59Z
dc.date.available2017-05-03T11:36:59Z
dc.date.issued2002
dc.date.modified2008-02-14T08:24:39Z
dc.identifier.issn0022-3042
dc.identifier.urihttp://hdl.handle.net/10072/16913
dc.description.abstractAlcoholism is a major health problem in Western countries, yet relatively little is known about the mechanisms by which chronic alcohol abuse causes the pathologic changes associated with the disease. It is likely that chronic alcoholism affects a number of signaling cascades and transcription factors, which in turn result in distinct gene expression patterns. These patterns are difficult to detect by traditional experiments measuring a few mRNAs at a time, but are well suited to microarray analyses. We used cDNA microarrays to analyze expression of approximately 10 000 genes in the frontal and motor cortices of three groups of chronic alcoholic and matched control cases. A functional hierarchy was devised for classification of brain genes and the resulting groups were compared based on differential expression. Comparison of gene expression patterns in these brain regions revealed a selective reprogramming of gene expression in distinct functional groups. The most pronounced differences were found in myelin-related genes and genes involved in protein trafficking. Significant changes in the expression of known alcohol-responsive genes, and genes involved in calcium, cAMP, and thyroid signaling pathways were also identified. These results suggest that multiple pathways may be important for neuropathology and altered neuronal function observed in alcoholism.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Publishing Ltd
dc.publisher.placeOxford, UK
dc.relation.ispartofpagefrom802
dc.relation.ispartofpageto813
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Neurochemistry
dc.relation.ispartofvolume81
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3209
dc.titlePatterns of gene expression are altered in the frontal and motor cortices of human alcoholics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2002
gro.hasfulltextNo Full Text
gro.griffith.authorLewohl, Joanne M.


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