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dc.contributor.authorCapuano, Ben
dc.contributor.authorT. Crosby, Ian
dc.contributor.authorJ. Lloyd, Edward
dc.contributor.authorNeve, Juliette
dc.contributor.authorA. Taylor, David
dc.date.accessioned2017-05-03T12:50:56Z
dc.date.available2017-05-03T12:50:56Z
dc.date.issued2007
dc.identifier.issn00049425
dc.identifier.doi10.1071/CH07197
dc.identifier.urihttp://hdl.handle.net/10072/16974
dc.description.abstractA series of substituted 1-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylhexahydropyrazin-1-ium]-1-aminimide derivatives were designed on the basis of the physicochemical properties of the aminimide functional group and synthesized as potential antipsychotic agents for the treatment of schizophrenia. The target compounds were readily prepared in two steps from clozapine (8-chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine) and involved N-acylation of a common hydrazinium salt intermediate by an acyl chloride or activated ester in the presence of a strong base. The aminimides were tested for in vitro activity at the dopamine D4 and serotonin 5-HT2A receptors and were found to possess modest affinity for both receptor systems.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.publisher.placeAustralia
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom673
dc.relation.ispartofpageto684
dc.relation.ispartofissue9
dc.relation.ispartofjournalAustralian Journal of Chemistry
dc.relation.ispartofvolume60
dc.rights.retentionY
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchcode03
dc.titleAminimides as Potential CNS Acting Agents. I. Design, Synthesis, and Receptor Binding of 4′-Aryl Aminimide Analogues of Clozapine as Prospective Novel Antipsychotics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2015-05-21T05:26:14Z
gro.hasfulltextNo Full Text
gro.griffith.authorNeve, Juliette E.


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