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dc.contributor.authorCapuano, Benen_US
dc.contributor.authorT. Crosby, Ianen_US
dc.contributor.authorJ. Lloyd, Edwarden_US
dc.contributor.authorNeve, Julietteen_US
dc.contributor.authorA. Taylor, Daviden_US
dc.date.accessioned2017-05-03T12:50:56Z
dc.date.available2017-05-03T12:50:56Z
dc.date.issued2007en_US
dc.identifier.issn00049425en_US
dc.identifier.doi10.1071/CH07197en_US
dc.identifier.urihttp://hdl.handle.net/10072/16974
dc.description.abstractA series of substituted 1-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylhexahydropyrazin-1-ium]-1-aminimide derivatives were designed on the basis of the physicochemical properties of the aminimide functional group and synthesized as potential antipsychotic agents for the treatment of schizophrenia. The target compounds were readily prepared in two steps from clozapine (8-chloro-11-(4-methylpiperazino)-5H-dibenzo[b,e][1,4]diazepine) and involved N-acylation of a common hydrazinium salt intermediate by an acyl chloride or activated ester in the presence of a strong base. The aminimides were tested for in vitro activity at the dopamine D4 and serotonin 5-HT2A receptors and were found to possess modest affinity for both receptor systems.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherCSIRO Publishingen_US
dc.publisher.placeAustraliaen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom673en_US
dc.relation.ispartofpageto684en_US
dc.relation.ispartofissue9en_US
dc.relation.ispartofjournalAustralian Journal of Chemistryen_US
dc.relation.ispartofvolume60en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode250301en_US
dc.titleAminimides as Potential CNS Acting Agents. I. Design, Synthesis, and Receptor Binding of 4′-Aryl Aminimide Analogues of Clozapine as Prospective Novel Antipsychoticsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2015-05-21T05:26:14Z
gro.hasfulltextNo Full Text
gro.griffith.authorNeve, Juliette E.


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