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dc.contributor.authorThomas, HL
dc.contributor.authorGajraj, R
dc.contributor.authorSlack, MPE
dc.contributor.authorSheppard, C
dc.contributor.authorHawkey, P
dc.contributor.authorGossain, S
dc.contributor.authorDrew, CM
dc.contributor.authorPebody, RG
dc.date.accessioned2018-05-08T01:32:23Z
dc.date.available2018-05-08T01:32:23Z
dc.date.issued2015
dc.identifier.issn0950-2688
dc.identifier.doi10.1017/S0950268814002490
dc.identifier.urihttp://hdl.handle.net/10072/172003
dc.description.abstractIn August 2012, an explosive outbreak of severe lower respiratory tract infection (LRTI) due to Streptococcus pneumoniae serotype-8 occurred in a highly vaccinated elderly institutionalized population in England. Fifteen of 23 residents developed LRTI over 4 days (attack rate 65%); 11 had confirmed S. pneumoniae serotype-8 disease, and two died. Following amoxicillin chemoprophylaxis and pneumococcal polysaccharide vaccine (PPV) re-vaccination no further cases occurred in the following 2 months. No association was found between being an outbreak-associated case and age (P = 0·36), underlying comorbidities [relative risk (RR) 0·84 95% confidence interval (CI) 0·34–2·09], or prior receipt of PPV (RR 1·4, 95% CI 0·60–3·33). However, the median number of years since PPV was significantly higher for cases (n = 15, 10·2 years, range 7·3–17·9 years) than non-cases (n = 8, 7·2 years, range 6·8–12·8 years) (P = 0·045), provided evidence of waning immunity. Alternative vaccination strategies should be considered to prevent future S. pneumoniae outbreaks in institutionalized elderly populations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherCambridge University Press
dc.relation.ispartofpagefrom1957
dc.relation.ispartofpageto1963
dc.relation.ispartofissue9
dc.relation.ispartofjournalEpidemiology and Infection
dc.relation.ispartofvolume143
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode111799
dc.subject.fieldofresearchcode1117
dc.titleAn explosive outbreak of Streptococcus pneumoniae serotype-8 infection in a highly vaccinated residential care home, England, Summer 2012
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.


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