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dc.contributor.authorThomas, HL
dc.contributor.authorGajraj, R
dc.contributor.authorSlack, MPE
dc.contributor.authorSheppard, C
dc.contributor.authorHawkey, P
dc.contributor.authorGossain, S
dc.contributor.authorDrew, CM
dc.contributor.authorPebody, RG
dc.description.abstractIn August 2012, an explosive outbreak of severe lower respiratory tract infection (LRTI) due to Streptococcus pneumoniae serotype-8 occurred in a highly vaccinated elderly institutionalized population in England. Fifteen of 23 residents developed LRTI over 4 days (attack rate 65%); 11 had confirmed S. pneumoniae serotype-8 disease, and two died. Following amoxicillin chemoprophylaxis and pneumococcal polysaccharide vaccine (PPV) re-vaccination no further cases occurred in the following 2 months. No association was found between being an outbreak-associated case and age (P = 0·36), underlying comorbidities [relative risk (RR) 0·84 95% confidence interval (CI) 0·34–2·09], or prior receipt of PPV (RR 1·4, 95% CI 0·60–3·33). However, the median number of years since PPV was significantly higher for cases (n = 15, 10·2 years, range 7·3–17·9 years) than non-cases (n = 8, 7·2 years, range 6·8–12·8 years) (P = 0·045), provided evidence of waning immunity. Alternative vaccination strategies should be considered to prevent future S. pneumoniae outbreaks in institutionalized elderly populations.
dc.publisherCambridge University Press
dc.relation.ispartofjournalEpidemiology and Infection
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchPublic Health and Health Services
dc.titleAn explosive outbreak of Streptococcus pneumoniae serotype-8 infection in a highly vaccinated residential care home, England, Summer 2012
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSlack, Mary P.

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